Actively Recruiting
Efficacy of Personalized Tumorogram-based Therapy in Cancer Established From Patient-derived Organoid (AVATAR)
Led by Institut Curie · Updated on 2026-01-29
110
Participants Needed
3
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A biopsy of a tumor lesion (breast or other localisation) will be performed for processing to establish avatars (patient-derived organoids -PDO). A personalized tumorogram for each patient will be provided, based on the results of the drug screening (= tumor predicted as sensitive, intermediate, resistant or non-evaluable for each drug tested). Patients with an informative tumorogram will receive one of the recommended treatments (line N+1) in the event of tumor progression, administered according to standard procedures and validated at medical meetings specific to each center, and their fate will be monitored.
CONDITIONS
Official Title
Efficacy of Personalized Tumorogram-based Therapy in Cancer Established From Patient-derived Organoid (AVATAR)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient over 18 years of age
- Advanced breast cancer
- Triple-negative phenotype (HR-/HER2-) or HR+/HER2- after hormone resistance (progression after treatment with hormone therapy + CDK4/6 inhibitor)
- Tumor measurable according to RECISTv1.1 criteria, accessible to biopsy
- Performance Status 0-1
You will not qualify if you...
- More than 3 lines of chemotherapy in the advanced setting (excluding hormone therapy/CDK4/6 inhibitor)
- Progressive brain metastases
- Leptomeningeal metastasis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Institut Curie
Paris, France, 75005
Actively Recruiting
2
Hôpital Saint-Louis - AP-HP Senopole
Paris, France, 75010
Not Yet Recruiting
3
Institut Curie
Saint-Cloud, France, 92210
Actively Recruiting
Research Team
L
Luc CABEL, MD
CONTACT
A
Anne-Sophie Plissonnier
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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