Actively Recruiting
Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.
Led by Institute of Hematology & Blood Diseases Hospital, China · Updated on 2025-08-05
6642
Participants Needed
4
Research Sites
338 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, randomized, double-blind controlled trial to evaluate the efficacy of placebo versus chlorpheniramine for the prevention of allergic transfusion reactions.
CONDITIONS
Official Title
Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 65 years old
- Diagnosed with a hematological disorder requiring blood product transfusions (such as suspended red blood cells, apheresis platelets, or fresh frozen plasma)
- Able to fully understand and voluntarily sign informed consent forms
You will not qualify if you...
- History of allergic diseases
- Experienced at least 1 moderate/severe or 2 mild allergic reactions previously
- Received glucocorticoid or allergy drugs within 24 hours before blood transfusion
- Transfused with washed red blood cells
- Received allo-hematopoietic stem cell transplantation before
- Have heart failure
- Suffer from lasting cardiovascular or cerebrovascular disease effects
- Pregnant or nursing women
- Unable to understand or follow study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Anhui Provincial Hospital
Hefei, Anhui, China
Not Yet Recruiting
2
Zhoukou Central Hospital
Zhoukou, Henan, China
Actively Recruiting
3
The Second Affilated Hospital of Shandong First Medical University
Tai’an, Shandong, China
Actively Recruiting
4
Regenerative Medicine Center
Tianjin, Tianjin Municipality, China
Actively Recruiting
Research Team
J
Jun Shi, PhD
CONTACT
J
Jingyu Zhao, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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