Treatment of Facial Contour Deformities Using Fat Grafts Enhanced with Curcumin-Preconditioned or Naive Adipose-Derived Stem Cells

What this Trial Is About

Researchers are investigating how well fat grafting enriched with adipose-derived stem cells ASCs, either preconditioned with curcumin or nave, compares to conventional fat grafting in correcting facial contour deformities that affect appearance. This Phase 1 randomized study focuses on patients with conditions such as Romberg disease, craniofacial microsomia, burn scars, and post-traumatic scars. The goal is to evaluate the therapeutic potential of these stem cell-enhanced fat grafts for aesthetic improvement. Participants will undergo fat harvesting through liposuction under sterile conditions. The harvested fat will be either mixed with cultured ASCs, cultured ASCs preconditioned with curcumin, or used alone for conventional grafting. For the stem cell groups, about 100,000 cells per ml of fat are injected into the facial deformity site. Stem cells are prepared by isolating them from adipose tissue, washing, enzymatic digestion, centrifugation, and culturing until ready for use. The curcumin preconditioning involves incubating the ASCs with curcumin for 24 hours before mixing with fat. During the study, participants will be monitored for changes in facial tissue volume using ultrasonography over 9 months. Both patient and surgeon assessments will also be collected at this time. Safety and cell viability are evaluated before transplantation. Participants are adults aged 18 to 50, and involvement includes surgical procedures, follow-up imaging, and assessments to measure treatment effects and safety over the study period.

Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting