Actively Recruiting
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Led by Loma Linda University · Updated on 2026-02-04
98
Participants Needed
1
Research Sites
284 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a double-blind, randomized, prospective, placebo-controlled single-center clinical research study in which 600 mg of gabapentin or placebo will be administered 2 hours preoperatively to 49 patients each undergoing wisdom teeth extraction. We will measure intraoperative opioid use, severity of pain, the number of analgesics taken, and side effect profiles (e.g. nausea/vomiting, dizziness) at the following intervals, 4 hour, 8 hour, 12 hour, 24, and 72 hour post-procedure.
CONDITIONS
Official Title
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects must be at or older than 18.
- Body mass index (BMI) between 18-35 kg/m2.
- American Society of Anesthesiologists Classification I and II.
- Willing and able to comply with protocol requirements.
- Able to understand and sign informed consent.
- Must have at least one partial or fully impacted third molar tooth removal.
You will not qualify if you...
- Hypersensitivity to gabapentinoids.
- History of chronic opioid or gabapentin use (regular use over 3 months).
- History of recreational drug use.
- Significant metabolic, hematologic, pulmonary, cardiovascular, gastrointestinal, neurologic, hepatic, renal, urologic, musculoskeletal, psychiatric, or immunologic disorder.
- Acute, clinically significant illness within 14 days prior to Day 1.
- Presence of baseline pain.
- Any oral pathology.
- Pregnant or breastfeeding.
- Not legally competent to consent (incapacitated, incompetent, minors).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Loma Linda University Health
Loma Linda, California, United States, 92354
Actively Recruiting
Research Team
J
Je Dong Ryu, DMD MD
CONTACT
S
Sung Han, DDS MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here