Reliability and Photographic Equivalency of the Scar Cosmesis Assessment and Rating (SCAR) Scale, an Outcome Measure for Postoperative Scars.
Jonathan Kantor
https://pubmed.ncbi.nlm.nih.gov/27806156Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID07269093
Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil
Led by Universiti Sains Malaysia · Updated on 2026-01-02
120
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of three different topical treatments—Chitosan cream, silicone gel, and olive oil—in preventing hypertrophic scars in adults whose scars have healed after suturing. This randomized controlled trial aims to compare these treatments to determine if Chitosan cream is as effective as the commonly used silicone gel and olive oil in scar prevention. The study involves adults with traumatic or surgical scars healed by primary intention within 14 days. Participants will be randomly assigned to one of three groups, each applying a different topical treatment twice daily for 8 weeks starting from the 14th day after wounding. The treatments being studied are Chitosan cream, silicone gel, and olive oil. This single-blinded study includes follow-up visits at 4, 12, and 24 weeks, during which scars will be assessed and photographed under standardized conditions. Participants will be monitored through clinical assessments using the Patient and Observer Scar Assessment Scale (POSAS) and photographs reviewed with the Scar Cosmesis and Assessment Rating (SCAR) Scale. Both patients and investigators will evaluate the scars at each visit. Any side effects will be reported immediately. The study duration spans from November 2025 to November 2026, with the main outcomes measured from enrollment up to 24 weeks.
CONDITIONS
Brief Title
Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients with traumatic or surgical wounds which have healed by primary intention within 14 days
- Length of scar at least 3cm
- Adults aged 18 to 65 years
You will not qualify if you...
- Patients with seafood allergy
- Patients with scar from wounds that were complicated by infection or wound breakdown
- Patients who have undergone scar treatment by other modalities
- Patients with history of keloids / hypertrophic scars
- Pregnant patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - 8 weeks
Participants apply their assigned topical product (Chitosan cream, silicone gel, or olive oil) twice daily starting from 14 days after wound healing to prevent hypertrophic scars.
1 baseline visit and 3 follow-up visits at weeks 4, 12, and 24
Long-term Monitoring
Duration - Up to 24 weeks from enrollment
Participants and investigators assess scar appearance through standardized scales and photographs to evaluate treatment efficacy and side effects.
Follow-up visits at weeks 4, 12, and 24 with scar assessments and photographs
Trial Site Locations
Total: 3 locations
1
Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, Malaysia, 15586
Not Yet Recruiting
2
Hospital Pakar Universiti Sains Malaysia
Kubang Kerian, Kelantan, Malaysia, 16150
Actively Recruiting
3
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, Malaysia, 50586
Not Yet Recruiting
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Research Team
E
Esther HM Tan, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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Published Research Related To This Trial
Development of the Patient Scale of the Patient and Observer Scar Assessment Scale (POSAS) 3.0: a qualitative study.
M E Carrière, L B Mokkink, Z Tyack...
https://pubmed.ncbi.nlm.nih.gov/36355319