Randomized Trial Comparing Chitosan Cream, Silicone Gel, and Olive Oil to Prevent Hypertrophic Scars in Adults

What this Trial Is About

Researchers are evaluating the effectiveness of three different topical treatmentsChitosan cream, silicone gel, and olive oilin preventing hypertrophic scars in adults whose scars have healed after suturing. This randomized controlled trial aims to compare these treatments to determine if Chitosan cream is as effective as the commonly used silicone gel and olive oil in scar prevention. The study involves adults with traumatic or surgical scars healed by primary intention within 14 days. Participants will be randomly assigned to one of three groups, each applying a different topical treatment twice daily for 8 weeks starting from the 14th day after wounding. The treatments being studied are Chitosan cream, silicone gel, and olive oil. This single-blinded study includes follow-up visits at 4, 12, and 24 weeks, during which scars will be assessed and photographed under standardized conditions. Participants will be monitored through clinical assessments using the Patient and Observer Scar Assessment Scale POSAS and photographs reviewed with the Scar Cosmesis and Assessment Rating SCAR Scale. Both patients and investigators will evaluate the scars at each visit. Any side effects will be reported immediately. The study duration spans from November 2025 to November 2026, with the main outcomes measured from enrollment up to 24 weeks.

Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil