Actively Recruiting
Efficacy of Preventive Ketamine on Postoperative Pain
Led by Ain Shams University · Updated on 2026-04-01
90
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
* Although bariatric surgery is mainly performed laparoscopically, analgesic optimization is still essential to reduce complications and to improve the patients' comfort. In laparoscopic sleeve gastrectomy, the intraoperative peritoneal instillation of bupivacaine hydrochloride (30 ml, 0.25%) was known to be safe and effective in reducing postoperative pain, nausea, and vomiting. * Furthermore, usage of ketamine both as a pre and post-operative pain management is well established. Ketamine can be used solely or in combination with other co-adjuvant drugs, increasing their efficacy. Many therapeutic properties of ketamine have been attributed to its antagonism mechanism to N-Methyl-D-aspartate receptors.
CONDITIONS
Official Title
Efficacy of Preventive Ketamine on Postoperative Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- - Body mass index > 35 and < 60 kg/m2
- Either medically free or with well controlled hypertension and/or diabetes.
You will not qualify if you...
- - Patient's refusal to participate in the study
- BMI > 60 kg/m2.
- Age less than 21 years.
- Patients with severe systemic disease which is not life-threatening.
- Patients on antipsychotics, antidepressants and/or corticosteroids.
- Patients with history of obstructive sleep apnea.
- Allergic reaction to any of the study medications.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ain-Shams University Hospitals
Cairo, Egypt
Actively Recruiting
Research Team
I
Ibrahim Mamdouh Esmat
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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