Study of Repeated Transcranial Magnetic Stimulation with Live Probiotic Tablets for Treating Diarrhea-Predominant Irritable Bowel Syndrome IBS-D

What this Trial Is About

Researchers are evaluating the overall effectiveness of repeated Transcranial Magnetic Stimulation rTMS combined with a Live Probiotic tablet containing Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus cereus in people with Diarrhea-Predominant Irritable Bowel Syndrome IBS-D. The study aims to improve symptoms including abdominal diarrhea, bowel issues, anxiety, depression, and sleep disturbances. It also explores how changes in intestinal flora may relate to treatment outcomes in IBS-D patients. The study involves 400 IBS patients randomized into four groups rTMS with Live Probiotic tablet, rTMS with placebo, sham rTMS with Live Probiotic tablet, and sham rTMS with placebo. Treatments last for 2 weeks. The rTMS groups receive brain stimulation at 1 Hz for 20 minutes daily or sham stimulation at 0 Hz for 20 minutes. The probiotic or placebo tablets are taken orally three times a day, 150 mg each dose. The trial includes a separate analysis of intestinal flora changes in 30 patients from each group before and after treatment. Participants will be assessed on symptoms, stool characteristics, mood, and sleep before treatment, immediately after the 2-week treatment, and followed for up to 3 months. Outcome measures include frequency of bowel movements, stool form scale scores, and IBS symptom severity scores. The study also monitors intestinal flora quantity and metabolism changes to understand treatment mechanisms. The total study duration allows for detailed evaluation of symptom changes and safety over time.

Efficacy of Repeated Transcranial Magnetic Stimulation Combined With a Live Probiotic Tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets, Live) in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)