Efficacy of a Mouthwash Containing Resveratrol in Reducing Halitosis-related P. gingivalis: A Randomized Triple-blind Trial.
Noor A Abed Taher, Athraa Ali Mahmood, Hashim Mueen Hussein
https://pubmed.ncbi.nlm.nih.gov/41328922Actively Recruiting
Phase 3
Age: 20Years - 24Years
All Genders
Healthy Volunteers
ID06882564
Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyromonas Gingivalis: A Randomized, Triple-blind Clinical Trial
Led by Al-Mustansiriyah University · Updated on 2025-03-18
54
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of an antioxidant mouthwash containing resveratrol in reducing oral malodor (bad breath) and the bacteria Porphyromonas gingivalis among undergraduate dental students with plaque-induced gingivitis. The study also aims to explore the relationship between this bacteria and clinical gum health measures such as plaque index, gingival index, and bleeding on probing. This is a randomized, triple-blind clinical trial involving students aged 20 to 23 without systemic diseases or recent periodontal treatment. Participants will be divided into three groups of 18 each. One group will use the resveratrol mouthwash, the second group will use chlorhexidine mouthwash as an active comparator, and the third will use distilled water as a placebo. All will rinse twice daily with 10 ml of the assigned mouthwash for 30 seconds, after brushing their teeth, over a 7-day period. They will be reminded twice daily by text message to maintain compliance and instructed to avoid eating or drinking for 30 minutes after rinsing. During the study, participants will complete questionnaires covering personal information, oral hygiene habits, and perceptions of oral malodor. Clinical assessments will include plaque index, gingival index, bleeding on probing, and organoleptic odor tests of the tongue and interdental areas. A portable sulfide monitor will confirm halitosis levels. These measures will be recorded at baseline and after 7 days of mouthwash use. Participants will also provide feedback on mouthwash taste and sensations using a visual scale. Safety monitoring includes advice to stop use if allergic reactions occur.
CONDITIONS
Brief Title
Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis.
Who Can Participate
Age: 20Years - 24Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Organoleptic tongue score greater than 2 on a 0-5 scale
- Male and female undergraduate dental students without chemical plaque control measures for at least one week
- Halitosis due to gingivitis
- Age between 20 and 23 years
- No periodontal treatment for at least one month
- No systemic disease
- No tobacco smoking
- At least 20 teeth present
You will not qualify if you...
- Smokers and alcoholics
- Periodontitis or pocket depth greater than 6 mm
- Orthodontic appliance wearer
- Open carious lesions, pericoronitis, dry socket, or fistula
- Systemic diseases or conditions
- Medication use within the last two weeks
- Consumption of garlic, onion, or licorice in the last 24 hours
- Use of oral hygiene products in the last 24 hours
- Pregnant women
- Sinusitis, tonsillitis, or upper respiratory tract infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 7 days
Participants use the assigned mouthwash twice daily for 7 days. They rinse with 10 ml of the mouthwash (resveratrol, chlorhexidine, or placebo) for 30 seconds after toothbrushing, and refrain from eating or drinking for 30 minutes after rinsing. Participants receive daily reminders to enhance compliance.
Baseline visit and 1 follow-up visit after 7 days
Trial Site Locations
Total: 1 location
1
Mustansiriyah University
Baghdad, Bab Al-Moadham, Iraq, 10047
Actively Recruiting
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Research Team
N
NOOR AA TAHER, B.D.S
N
NOOR AA TAHER, B.D.S
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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