Study of Resveratrol Mouthwash to Reduce Bad Breath and Gum Disease in Dental Students Aged 20 to 24

What this Trial Is About

Researchers are evaluating the effectiveness of an antioxidant mouthwash containing resveratrol in reducing oral malodor bad breath and the bacteria Porphyromonas gingivalis among undergraduate dental students with plaque-induced gingivitis. The study also aims to explore the relationship between this bacteria and clinical gum health measures such as plaque index, gingival index, and bleeding on probing. This is a randomized, triple-blind clinical trial involving students aged 20 to 23 without systemic diseases or recent periodontal treatment. Participants will be divided into three groups of 18 each. One group will use the resveratrol mouthwash, the second group will use chlorhexidine mouthwash as an active comparator, and the third will use distilled water as a placebo. All will rinse twice daily with 10 ml of the assigned mouthwash for 30 seconds, after brushing their teeth, over a 7-day period. They will be reminded twice daily by text message to maintain compliance and instructed to avoid eating or drinking for 30 minutes after rinsing. During the study, participants will complete questionnaires covering personal information, oral hygiene habits, and perceptions of oral malodor. Clinical assessments will include plaque index, gingival index, bleeding on probing, and organoleptic odor tests of the tongue and interdental areas. A portable sulfide monitor will confirm halitosis levels. These measures will be recorded at baseline and after 7 days of mouthwash use. Participants will also provide feedback on mouthwash taste and sensations using a visual scale. Safety monitoring includes advice to stop use if allergic reactions occur.

Efficacy of Resveratrol Containing Mouthwash in Reducing Halitosis Related Porphyrymonas Gingivalis.