Actively Recruiting
Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM
Led by Zhongda Hospital · Updated on 2024-06-07
30
Participants Needed
1
Research Sites
79 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To observe the PFS of yttrium \[90Y\] microsphere injection combined with FOLFIRI and bevacizumab in second-line treatment of CRLM.
CONDITIONS
Official Title
Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Signed informed consent voluntarily
- Liver metastases from colorectal cancer with colorectal cancer lesions removed
- Liver metastases limited to a single lobe
- Liver tumor progressed after first-line treatment
- Planned treatment with FOLFIRI combined with bevacizumab
- Eligible and planned for yttrium [90Y] microsphere injection treatment
- KRAS gene mutation present
- Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
- Child Pugh score of 7 or less
- Adequate organ function including hematology, liver, kidney, and coagulation within specified limits
You will not qualify if you...
- Previous external radiation therapy or transhepatic arterial chemoembolization for liver metastases
- Presence of metastases outside the liver
- Pregnant or breastfeeding women
- History of severe arrhythmia or heart failure
- Considered unsuitable for participation by other researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zhongda Hospital，Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
Research Team
H
Hai-Dong Zhu
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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