Actively Recruiting
Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris
Led by Badr University · Updated on 2025-08-03
120
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acne vulgaris affects around 85% of adolescents and young adults. Adapalene, a topical retinoid, is a common treatment but often causes irritation, leading to poor adherence. Hyaluronic acid (HA), known for its hydrating and anti-inflammatory properties, may help reduce these side effects. This prospective, open-label, randomized controlled trial compares adapalene 0.1% gel combined with HA serum versus adapalene alone over 8 weeks in patients with mild to moderate acne. Key outcomes include acne lesion reduction, incidence and severity of side effects (erythema, dryness, scaling, stinging/burning, pruritus), and skin hydration assessed through the skin turgor test. Acne severity will be measured using the Acne Severity Index (ASI) and Investigator's Global Assessment (IGA) scale. The study anticipates better efficacy, reduced irritation, and improved skin hydration with the combination therapy. Ethical approval was obtained, and informed consent will be secured from all participants.
CONDITIONS
Official Title
Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with mild to moderate acne vulgaris
- No use of topical retinoids or systemic acne treatments within the past 3 months
You will not qualify if you...
- Severe acne or nodulocystic acne
- Secondary infections
- Known hypersensitivity to adapalene or hyaluronic acid
- Pregnant or lactating individuals
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Badr university in Cairo
Cairo, Cairo Governorate, Egypt, 11829
Actively Recruiting
Research Team
H
Hebatallah Moustafa, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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