Comparing the Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris: An Open-label Randomized Controlled Trial

What this Trial Is About

Acne vulgaris is a common skin condition affecting about 85% of adolescents and young adults, often treated with topical retinoids like adapalene. This trial studies the effects of combining adapalene 0.1% gel with hyaluronic acid (HA) serum compared to adapalene alone in patients with mild to moderate acne. The goal is to see if the combination reduces acne lesions and lessens side effects such as redness, dryness, scaling, stinging, burning, and itching while improving skin hydration. The study is an open-label, randomized controlled trial lasting 8 weeks. Participants are divided into two groups: one uses adapalene 0.1% gel nightly with HA serum, and the other uses adapalene gel alone at bedtime. Assessments occur at the start and at weeks 2, 4, and 8 to monitor treatment effects, side effects, and skin hydration. During the trial, acne severity is measured with the Acne Severity Index and Investigator's Global Assessment scale, while skin hydration is evaluated using the skin turgor test. Side effects are scored for severity at each visit. Researchers aim to determine if the combination therapy improves acne outcomes and reduces irritation. All participants will provide informed consent, and data confidentiality is maintained throughout the study.

Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris