Actively Recruiting
A Retrospective Clinical Study on the Efficacy and Safety of Amphotericin B Compared With Azoles in the Treatment of Invasive Fungal Disease
Led by Sichuan Provincial People's Hospital · Updated on 2025-02-11
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the effectiveness and safety of two types of antifungal drugs, amphotericin B and azoles, in patients with invasive fungal disease. The study collects medical records, demographic details, and clinical data from patients treated at Sichuan Provincial People's Hospital between 2021 and 2024 to compare these treatments. The purpose is to better understand how these drugs perform in real clinical settings to inform future care. Patients receive treatment with either polyene antifungal drugs, such as amphotericin B or its cholesteryl sulphate complex, or azole antifungal drugs, including triazoles or imidazoles. The dosage and length of treatment for both drug types are determined by clinicians based on clinical practice. The study is observational, recording outcomes as patients undergo their prescribed treatments. Participants contribute by allowing access to their medical records and clinical data for analysis. Researchers assess the clinical success rate at the end of treatment and up to one year afterward. Safety is monitored during treatment, at day 14, and at day 28 after treatment starts. The study does not involve additional interventions or procedures, focusing on data collection and evaluation over several months.
CONDITIONS
Brief Title
Efficacy and Safety of Amphotericin B and Azoles in the Treatment of Invasive Fungal Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- There is no age limit, gender is not limited
- Patients with invasive fungal disease who are treated with polyene antifungals or azole antifungals should be treated for 7 days
You will not qualify if you...
- Patients with incomplete data or other factors affecting the clinical outcome judgement
- Patients who are judged by the investigator to be unsuitable to participate in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Retrospective collection of medical records from 2021 to 2024
Duration - At least 7 days
Participants receive treatment with either amphotericin B or azole antifungal drugs as determined by their clinicians.
Treatment duration varies per clinical practice, monitored up to 14 days with safety assessments
Duration - Up to 1 year
Participants are observed for safety and clinical success up to 1 year after treatment.
Safety assessments during treatment and at Day 28; clinical success evaluated at the end of treatment up to 1 year
Trial Site Locations
Total: 1 location
1
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China, 610072
Actively Recruiting
Research Team
L
lingai Pan, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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