Evaluating the Safety and Effectiveness of a Botanical Total Coumarin Cream in Adults With Psoriasis Vulgaris A Phase III, Double-Blind, Randomized, Placebo-Controlled Study Using Topical Treatment Over 8 Weeks

What this Trial Is About

Researchers are evaluating a botanical Total Coumarin topical cream TC Cream to see if it helps treat psoriasis vulgaris in adults and to assess its safety. The study compares TC Cream to a placebo cream without active ingredients. The main questions focus on whether TC Cream improves psoriasis symptoms, what medical issues may arise during use, and if it enhances quality of life for those affected. Participants will be randomly assigned to one of two groups one applying TC Cream and the other applying a placebo cream. Both groups will apply their assigned cream twice daily for 8 weeks. They will visit the clinic every 2 weeks for checkups and tests. The TC Cream is a botanical drug approved in China and studied in previous trials. The placebo cream looks the same but contains no active drug. During the study, participants will have their skin examined and psoriasis severity measured using several scales, including the Investigators Global Assessment and Psoriasis Area and Severity Index. They will also track symptoms and side effects in a diary. Quality of life will be assessed with questionnaires. Follow-up assessments occur 4 weeks after treatment ends. The involvement lasts for 12 weeks including a 4-week post-treatment observation period.

Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III)