Actively Recruiting
Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III)
Led by Psoriasis Research Institute of Guangzhou · Updated on 2026-02-23
300
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a botanical Total Coumarin topical cream (TC Cream) works to treat psoriasis in adults. It will also learn about the safety of the topical TC Cream. The main questions it aims to answer are: * Does TC Cream improve the psoriasis disease symptoms? * What medical problems do participants have when applying TC Cream? * Does TC Cream improve the quality of life of psoriasis patients? Researchers will compare TC Cream to a placebo cream (a look-alike cream that contains no active drug) to see if TC Cream works to treat psoriasis. Participants will: * Topically apply the TC Cream or a placebo cream twice daily every day to affected skin for 8 weeks * Visit the clinic once every 2 weeks for checkups and tests * Keep a diary of their symptoms and their diseased skin conditions during the application of the topical cream
CONDITIONS
Official Title
Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old, any gender, and any race or ethnic group
- Diagnosed with stable phase psoriasis vulgaris with at least two target lesions suitable for evaluation
- Women of childbearing age must use birth control methods such as condoms or oral contraceptives during the 8-week study
- Investigator's Global Assessment (IGA) score of 2 or higher (mild severity or above)
- Body surface area (BSA) affected between 1% and 20%
- Signed informed consent
- No additional sun exposure during the study period
You will not qualify if you...
- Pregnant, breastfeeding, or preparing for pregnancy
- History of allergic or photosensitivity reactions
- History of serious cardiovascular, cerebrovascular, liver, kidney, blood system diseases, or psychiatric disorders
- History of photosensitive diseases like porphyria or xeroderma pigmentosa
- Used topical psoriasis treatments, PUVA, UVB, or Grenz ray therapy within 4 weeks before randomization
- Used systemic psoriasis treatments (except biologics) or investigational therapies within 4 weeks before randomization
- Used systemic retinoids or biologic therapies within 3 months before randomization
- Planning to start or change medications affecting psoriasis during the study
- History of allergic reactions to compounds similar to coumarins
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Dermatology, SUNY Downstate Health Sciences University
New York, New York, United States, 11203
Actively Recruiting
Research Team
J
Jiang Yang, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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