Actively Recruiting
Led by University Hospital, Antwerp · Updated on 2025-04-03
100
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying patients with acute kidney injury (AKI) who require continuous renal replacement therapy (CRRT), focusing on those with liver failure or significant liver dysfunction and severe shock. The goal is to understand how different causes of liver failure affect the safety and effectiveness of using citrate as an anticoagulant during CRRT. This retrospective cohort study aims to clarify the risks of citrate-related complications and compare treatment outcomes in this vulnerable population. Citrate anticoagulation works by binding calcium to prevent blood clotting in the CRRT circuit, and is usually processed by the liver. However, impaired liver function can cause citrate to build up, potentially leading to metabolic problems. This study will assess whether the cause of liver failure influences the frequency of such complications. It also compares kidney recovery, filter lifespan, and patient survival between patients with liver failure or dysfunction and those with severe shock. Participants' medical records will be reviewed during their ICU admission to evaluate citrate-related safety outcomes and treatment effectiveness. Researchers will analyze data on metabolic status, filter performance, and survival rates. The study focuses on the time patients spend receiving CRRT in the ICU to measure these outcomes and gather insights on managing anticoagulation in this high-risk group.
CONDITIONS
Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications
You may qualify if you...
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - During ICU admission
Participants who undergo routine care with continuous renal replacement therapy (CRRT) and citrate anticoagulation are observed to evaluate safety and complications related to citrate use in the context of liver failure or dysfunction.
Ongoing assessments during ICU stay
Total: 1 location
1
Antwerp University Hospital
Edegem, Antwerp, Belgium, 2650
Actively Recruiting
R
Rita Jacobs, Dr.
P
Petra Vertongen
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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