Actively Recruiting
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
Led by Cairo University · Updated on 2024-07-24
110
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
Sponsors
C
Cairo University
Lead Sponsor
N
National Heart Institute, Egypt
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to compare two medications, acetazolamide and metolazone, along with loop diuretics, to see which one works better and is safer for patients with ADHF who have volume overload. By comparing these medications, we hope to learn which one can help these patients the most. This will help doctors choose the best treatment for patients with ADHF and volume overload.
CONDITIONS
Official Title
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients aged 18 years or older and under 65 years
- Clinical diagnosis of acute decompensated heart failure with at least one sign of volume overload such as edema (score 2 or higher), ascites confirmed by ultrasound, pleural effusion confirmed by X-ray or ultrasound, rales on lung exam, or jugular venous pressure above 10 mm Hg
- Eligible for both elective and emergency hospital admissions
You will not qualify if you...
- Acute kidney injury on admission defined by specific increases in serum creatinine or low urine output
- Acute pulmonary edema caused by increased afterload without significant fluid accumulation
- Planned exposure to kidney-toxic agents during hospital stay
- Anuria or receiving renal replacement therapy or ultrafiltration
- Estimated glomerular filtration rate below 30 mL/min/1.73m² at screening
- Expected need for intravenous inotropes, vasopressors, or nitroprusside during the study
- Previous heart transplant or use of a ventricular assist device
- Blood pressure below 90 mmHg or mean arterial pressure below 65 mmHg at recruitment
- Pregnancy or breastfeeding
- Use of acetazolamide or metolazone within one month before randomization
- Use of diuretics other than mineralocorticoid receptor antagonists during treatment phase
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Heart Institute
Giza, GZ, Egypt, 3755204
Actively Recruiting
Research Team
M
Mohamed AN Abdelmoaty, B.Sc. Pharmaceutical Sciences
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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