Actively Recruiting
Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial
Led by Yanqing Li · Updated on 2026-04-15
372
Participants Needed
2
Research Sites
68 weeks
Total Duration
On this page
Sponsors
Y
Yanqing Li
Lead Sponsor
L
Longkou People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a multicentre, non-inferiority randomized controlled trial to compare the efficacy and safety of 14-day vonoprazan-based dual therapy with versus quadruple therapy for the eradication of Helicobacter pylori. The primary outcome is eradication rate, and the secondary outcome includes the incidence of adverse events and compliance.
CONDITIONS
Official Title
Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18-70 years, male or female
- Confirmed H. pylori infection by positive 13C-urea breath test plus at least one positive result from stool antigen test, rapid urease test, or gastric mucosal biopsy
- No prior treatment to eradicate Helicobacter pylori
You will not qualify if you...
- Severe underlying conditions such as liver or kidney failure, or cancer
- Active gastrointestinal bleeding
- History of upper gastrointestinal surgery
- History of drug allergies
- Use of bismuth compounds or antibiotics within the past 4 weeks, or acid-suppressing drugs within the past 2 weeks
- Pregnant or breastfeeding women
- Risk behaviors like alcohol abuse or illicit drug use
- Unable or unwilling to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Actively Recruiting
2
Qilu Hospital of Shandong University
Jinan, China
Not Yet Recruiting
Research Team
Y
Yueyue Li
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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