Actively Recruiting
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Led by Eli Lilly and Company · Updated on 2026-05-14
900
Participants Needed
159
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.
CONDITIONS
Official Title
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m8) or higher at screening
- Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Have osteoarthritis of the knee and at least one of the following: be over 50 years old, have morning knee stiffness lasting about 30 minutes, or have a crackling or grinding sound or feeling in the knee
You will not qualify if you...
- Have had prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if done more than 1 year before screening)
- Have had prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device treatment allowed if device was removed more than 6 months before screening)
- Have type 1 diabetes, type 2 diabetes, or any other diabetes
- Have an active knee infection
- Have had a heart attack, stroke, coronary artery revascularization, unstable angina, or hospitalization due to congestive heart failure within 90 days before screening
- Have New York Heart Association Functional Classification Class IV congestive heart failure
- Have taken weight loss medications or alternative remedies within 90 days before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 159 locations
1
AMR Clinical
Mobile, Alabama, United States, 36608
Actively Recruiting
2
Care Access - 801 South Power Road, Mesa
Mesa, Arizona, United States, 85206
Actively Recruiting
3
Elite Pain and Spine Institute - South Crimson Road
Mesa, Arizona, United States, 85209
Actively Recruiting
4
Tucson Orthopaedic Institute - North Wyatt Drive
Tucson, Arizona, United States, 85712
Actively Recruiting
5
Ark Clinical Research - Fountain Valley
Fountain Valley, California, United States, 92708
Actively Recruiting
6
Wolverine Clinical Trials
Santa Ana, California, United States, 92706
Actively Recruiting
7
Encompass Clinical Research
Spring Valley, California, United States, 91978
Actively Recruiting
8
Diablo Clinical Research, Inc.
Walnut Creek, California, United States, 94598
Actively Recruiting
9
Westside Center for Clinical Research
Jacksonville, Florida, United States, 32205
Actively Recruiting
10
Care Access - St. Petersburg
St. Petersburg, Florida, United States, 33710
Actively Recruiting
11
Conquest Research
Winter Park, Florida, United States, 32789
Actively Recruiting
12
Orita Clinical Research
Decatur, Georgia, United States, 30034
Actively Recruiting
13
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States, 60640
Actively Recruiting
14
Qualmedica Research, LLC
Evansville, Indiana, United States, 47715
Actively Recruiting
15
AMR Clinical
Newton, Kansas, United States, 67114
Actively Recruiting
16
Monroe Biomedical Research - Louisville
Louisville, Kentucky, United States, 40213
Actively Recruiting
17
Skylight Health Research - Burlington
Burlington, Massachusetts, United States, 01803
Actively Recruiting
18
Care Access - Quincy
Quincy, Massachusetts, United States, 02169
Not Yet Recruiting
19
Ellipsis Research Group - Brooklyn - 7th Street
Brooklyn, New York, United States, 11215
Actively Recruiting
20
Rochester Clinical Research - Buffalo
Buffalo, New York, United States, 14127
Actively Recruiting
21
NYC Research INC
Long Island City, New York, United States, 11106
Actively Recruiting
22
Rochester Clinical Research, LLC
Rochester, New York, United States, 14609
Actively Recruiting
23
Central States Research
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
24
Heritage Valley Multispecialty Group, Inc
Beaver, Pennsylvania, United States, 15009
Not Yet Recruiting
25
Keystone Clinical Studies
Plymouth Meeting, Pennsylvania, United States, 19462
Actively Recruiting
26
JCCT - Juno Bellaire Site
Bellaire, Texas, United States, 77401
Actively Recruiting
27
Epic Medical Research - DeSoto
DeSoto, Texas, United States, 75115
Actively Recruiting
28
Valley Institute of Research - Fort Worth
Fort Worth, Texas, United States, 76164
Actively Recruiting
29
Care Access - Houston
Houston, Texas, United States, 77054
Actively Recruiting
30
VIP Trials
San Antonio, Texas, United States, 78230
Actively Recruiting
31
Endeavor Clinical Trials
San Antonio, Texas, United States, 78240
Actively Recruiting
32
Consano Clinical Research, LLC
Shavano Park, Texas, United States, 78231
Actively Recruiting
33
Texas Valley Clinical Research
Weslaco, Texas, United States, 78596
Actively Recruiting
34
AMR Clinical
South Jordan, Utah, United States, 84095
Actively Recruiting
35
Centro Privado de Medicina Familiar / Mindout Research
Buenos Aires, Argentina, 1417
Not Yet Recruiting
36
CARDIAMET Investigaciones Médicas
Buenos Aires, Argentina, C1014ACP
Not Yet Recruiting
37
Organizacion Medica de Investigacion
Buenos Aires, Argentina, C1015ABO
Not Yet Recruiting
38
Stat Research S.A.
Buenos Aires, Argentina, C1023AAB
Not Yet Recruiting
39
Centro Médico Arsema
Buenos Aires, Argentina, C1427CCL
Not Yet Recruiting
40
APRILLUS Asistencia E Investigacion
CABA, Argentina, 1406
Not Yet Recruiting
41
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Argentina, 2152
Not Yet Recruiting
42
INECO Neurociencias Oroño
Rosario, Argentina, 2000
Not Yet Recruiting
43
Instituto Especialidades de la Salud Rosario
Rosario, Argentina, 2000
Not Yet Recruiting
44
Medicina Reumatológica
San Fernando, Argentina, 1646
Not Yet Recruiting
45
Instituto de Alta Complejidad San Isidro
San Isidro, Argentina, 1642
Not Yet Recruiting
46
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
San Juan, Argentina, 5400
Not Yet Recruiting
47
Centro de Investigaciones Médicas Tucuman
SAN M. de Tucuman, Argentina, T4000AXL
Not Yet Recruiting
48
Centro de Investigaciones Reumatológicas
San Miguel de Tucumán, Argentina, 4000
Not Yet Recruiting
49
Go Centro Medico San Nicolás
San Nicolás, Argentina, 2900
Not Yet Recruiting
50
Antwerp University Hospital
Edegem, Belgium, 2650
Not Yet Recruiting
51
Reuma Clinic, Locatie Jaarbeurslaan
Genk, Belgium, 3600
Not Yet Recruiting
52
UZ Gent
Ghent, Belgium, 9000
Actively Recruiting
53
Kormont
Kluisbergen, Belgium, 9690
Not Yet Recruiting
54
UZ Leuven
Leuven, Belgium, 3000
Not Yet Recruiting
55
Meclinas
Mechelen, Belgium, 2800
Actively Recruiting
56
ZNA Jan Palfijn
Merksem, Belgium, 2170
Not Yet Recruiting
57
Medisch Centrum Latem (Hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location
Sint-Martens-Latem, Belgium, 9830
Not Yet Recruiting
58
Centro de Pesquisa Sao Lucas
Campinas, Brazil, 13060-803
Not Yet Recruiting
59
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, Brazil, 20241-180
Not Yet Recruiting
60
CPHosp Medicina, Ensino e Pesquisa (CPQuali)
São Paulo, Brazil, 01228-000
Not Yet Recruiting
61
INTEGRA - Pesquisa Clínica e Infusões
São Paulo, Brazil, 04039-002
Not Yet Recruiting
62
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, Brazil, 04266-010
Not Yet Recruiting
63
Hospital das Clinicas FMUSP
São Paulo, Brazil, 05403-000
Not Yet Recruiting
64
Apex Trials
Guelph, Canada, N1G 0B4
Actively Recruiting
65
G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
Québec, Canada, G1V 3M7
Not Yet Recruiting
66
Diex Recherche Inc. Division Quebec
Québec, Canada, G1V 4T3
Actively Recruiting
67
Stouffville Medical Research Institute Inc.
Stouffville, Canada, L4A 1H2
Actively Recruiting
68
Maple Leaf Research
Toronto, Canada, M5G 1K2
Actively Recruiting
69
Dr. Anil K. Gupta Medicine Professional Corporation
Toronto, Canada, M9V 4B4
Actively Recruiting
70
Diex Recherche Inc. Division Victoriaville
Victoriaville, Canada, G6P 3Z8
Actively Recruiting
71
Beijing Ji Shui Tan Hospital
Beijing, China, 100035
Not Yet Recruiting
72
The First Afflilated Hospital of Bengbu Medical College
Bengbu, China, 233004
Not Yet Recruiting
73
Jilin Province People's Hospital
Changchun, China, 130021
Not Yet Recruiting
74
The Second Hospital of Jilin University
Changchun, China, 130041
Not Yet Recruiting
75
Xiangya Hospital Central South University
Changsha, China, 410008
Not Yet Recruiting
76
2nd Affiliated Hospital Chongqing Medical Universi
Chongqing, China, 400000
Not Yet Recruiting
77
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, China, 350005
Not Yet Recruiting
78
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, China, 310016
Not Yet Recruiting
79
The Second Affiliated hospital of Zhejiang University school of medicine
Hangzhou, China, 310052
Not Yet Recruiting
80
The Second People's Hospital of Hefei
Hefei, China, 230011
Not Yet Recruiting
81
Jinan Central Hospital
Jinan, China, 250013
Not Yet Recruiting
82
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, China, 471003
Not Yet Recruiting
83
Nanjing First Hospital
Nanjing, China, 210006
Not Yet Recruiting
84
Zhongda Hospital Southeast University
Nanjing, China, 210009
Not Yet Recruiting
85
The first affiliated hospital of Ningbo university
Ningbo, China, 315010
Not Yet Recruiting
86
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, 200023
Not Yet Recruiting
87
Zhongshan Hospital,Fudan University
Shanghai, China, 200032
Not Yet Recruiting
88
Huashan Hospital, Fudan University
Shanghai, China, 200040
Not Yet Recruiting
89
The University of Hong Kong-Shenzhen Hospital
Shenzhen, China, 518053
Not Yet Recruiting
90
The Second Affiliated Hospital of Soochow University
Suzhou, China, 215004
Not Yet Recruiting
91
Tianjin Hospital
Tianjin, China, 300211
Not Yet Recruiting
92
The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, China, 315100
Not Yet Recruiting
93
Tongji Hospital Tongji Medical,Science & Technology
Wuhan, China, 430030
Not Yet Recruiting
94
Xianyang Hospital of Yan'an University
Xianyang, China, 712000
Not Yet Recruiting
95
Pratia Brno
Brno, Czechia, 602 00
Actively Recruiting
96
Revmatologie.s.r.o.
Brno, Czechia, 63800
Actively Recruiting
97
INREA s.r.o.
Ostrava, Czechia, 70300
Actively Recruiting
98
Pratia Pardubice a.s.
Pardubice, Czechia, 53002
Actively Recruiting
99
Medical Plus Research
Uherské Hradiště, Czechia, 686 01
Actively Recruiting
100
Sanos Clinic - Nordjylland
Gandrup, Denmark, 9362
Actively Recruiting
101
Sanos Clinic
Herlev, Denmark, 2730
Actively Recruiting
102
Sanos Clinic - Syddanmark
Vejle, Denmark, 7100
Actively Recruiting
103
Siteworks GmbH - Bochum
Bochum, Germany, 44787
Not Yet Recruiting
104
Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
Bünde, Germany, 32257
Not Yet Recruiting
105
StudyPoint Duisburg
Duisburg, Germany, 47269
Not Yet Recruiting
106
HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
Hamburg, Germany, 20095
Not Yet Recruiting
107
Siteworks - Karlsruhe
Karlsruhe, Germany, 76137
Not Yet Recruiting
108
AmBeNet GmbH
Leipzig, Germany, 04107
Not Yet Recruiting
109
CDG Studienambulanz Hartard
München, Germany, 80809
Not Yet Recruiting
110
Dedicated Research Site FutureMeds
Offenbach, Germany, 63065
Not Yet Recruiting
111
National Hospital Organization Chiba Medical Center
Chiba, Japan, 260-8606
Actively Recruiting
112
Tokyo-Eki Center-building Clinic
Chūōku, Japan, 103-0027
Actively Recruiting
113
Tokyo Asbo Clinic
Chūōku, Japan, 104-0031
Actively Recruiting
114
Shin Komonji Hospital
Kitakyushu-Shi, Japan, 800-0057
Actively Recruiting
115
Goto Orthopedic Surgery Clinic
Miyazaki, Japan, 880-0835
Actively Recruiting
116
Komagidai Clinic
Nagareyama, Japan, 270-0113
Actively Recruiting
117
Fujigaki Clinic
Ōita, Japan, 870-0942
Actively Recruiting
118
Saitama City Hospital
Saitama, Japan, 336-8522
Actively Recruiting
119
Ibaraki Seinan Medical Center Hospital
Sashima, Japan, 306-0433
Not Yet Recruiting
120
Ogura Orthopedics Surgery
Sendai, Japan, 980-0011
Actively Recruiting
121
Katsura Garden Orthopedics
Sendai, Japan, 981-3134
Not Yet Recruiting
122
Ooimachi Orthopedic Surgery and surgery Clinic
Shinagawa-ku Tokyo, Japan, 140-0014
Not Yet Recruiting
123
Masumoto Orthopedics Clinic
Suginami City, Japan, 167-0051
Actively Recruiting
124
National Hospital Organization Toyohashi Medical Center
Toyohashi, Japan, 440-8510
Actively Recruiting
125
Yamagata Tokushukai Hospital
Yamagata, Japan, 990-0834
Actively Recruiting
126
Investigacion y Biomedicina de Chihuahua
Chihuahua City, Mexico, 31000
Not Yet Recruiting
127
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
Ciudad Madero, Mexico, 89440
Not Yet Recruiting
128
Diseno y Planeacion en Investigacion Medica - Guadalajara - Calle Amado Nervo
Guadalajara, Mexico, 44600
Not Yet Recruiting
129
Unidad de Investigación Clínica y Atención Médica HEPA S.C.
Guadalajara, Mexico, 44670
Not Yet Recruiting
130
RM Pharma Specialists - Unidad Especializada en Datos
Mexico City, Mexico, 03100
Not Yet Recruiting
131
Kohler & Milstein Research S.A. De C.V.
Mérida, Mexico, 97070
Not Yet Recruiting
132
IMED Internal Medicine Clin Trials
Monterrey, Mexico, 64020
Not Yet Recruiting
133
UBAM Unidad Biomedica Avanzada Monterrey
Monterrey, Mexico, 64460
Not Yet Recruiting
134
Centro de investigación y control metabólico
Monterrey, Mexico, 66465
Not Yet Recruiting
135
Dorado Medical Complex
Dorado, Puerto Rico, 00646
Actively Recruiting
136
GCM Medical Group, PSC - Hato Rey Site
San Juan, Puerto Rico, 00917
Actively Recruiting
137
Keimyung University Dongsan Hospital
Daegu, South Korea, 42601
Not Yet Recruiting
138
Boramae Medical Center
Dongjak-gu, South Korea, 07061
Not Yet Recruiting
139
Seoul National University Hospital
Seoul, South Korea, 03080
Not Yet Recruiting
140
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Not Yet Recruiting
141
Asan Medical Center
Seoul, South Korea, 05505
Not Yet Recruiting
142
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, South Korea, 06591
Not Yet Recruiting
143
Hallym University Kangnam Sacred Heart Hospital
Seoul, South Korea, 07441
Not Yet Recruiting
144
The Catholic University of Korea, Uijeongbu St. Mary's Hospital
Uijeongbu-si, South Korea, 11765
Not Yet Recruiting
145
Changhua Christian Hospital
Changhua County, Taiwan, 50006
Not Yet Recruiting
146
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, Taiwan, 83301
Not Yet Recruiting
147
China Medical University Hospital
Taichung, Taiwan, 404332
Not Yet Recruiting
148
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Not Yet Recruiting
149
National Taiwan University Hospital
Taipei, Taiwan, 10002
Not Yet Recruiting
150
Taipei Medical University Hospital
Taipei, Taiwan, 110
Not Yet Recruiting
151
Tri-Service General Hospital
Taipei, Taiwan, 114
Not Yet Recruiting
152
Velocity Clinical Research, Bristol
Bristol, United Kingdom, BS8 2RA
Not Yet Recruiting
153
FutureMeds Glasgow - CPS Research
Glasgow, United Kingdom, G20 7BE
Not Yet Recruiting
154
FutureMeds - London
London, United Kingdom, NW10 2PB
Not Yet Recruiting
155
Futuremeds-Newcastle
Newcastle, United Kingdom, NE6 1SG
Not Yet Recruiting
156
Atlantic Medical
Penzance, United Kingdom, TR18 3DX
Not Yet Recruiting
157
Woodstock Bower Surgery
Rotherham, United Kingdom, S61 1AH
Not Yet Recruiting
158
Panthera Biopartners - Sheffield
Sheffield, United Kingdom, S2 5FX
Not Yet Recruiting
159
Panthera Clinic - York
York, United Kingdom, YO24 4LJ
Not Yet Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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