Actively Recruiting
Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
Led by Beijing Tiantan Hospital · Updated on 2026-05-05
224
Participants Needed
1
Research Sites
215 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to assess the efficacy and safety of endovascular treatment versus medical management in patients with acute basilar artery occlusion with extended time window of 24-72 hours from onset.
CONDITIONS
Official Title
Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Acute basilar artery occlusion confirmed by CTA, MRA, or DSA
- Pre-stroke modified Rankin scale score of 0 to 2
- NIHSS score of 10 or higher before randomization
- Time from symptom onset or last known well to randomization between 24 and 72 hours
- Diffusion-weighted imaging-based pc-ASPECTS score of 6 or higher and Pons-Midbrain Index of 3 or less
- Time from completion of diffusion-weighted imaging to randomization is 3 hours or less
- Written informed consent provided by patient or legal representative
You will not qualify if you...
- Any sign of intracranial hemorrhage (except microbleeds) on brain imaging before randomization
- Complete cerebellar infarct with significant mass effect or bilateral thalamic infarction
- CT or MRI evidence of intracranial tumor except small meningioma and cerebral aneurysm smaller than 3 mm diameter
- Known or suspected chronic occlusion of the basilar artery
- History of contraindication to contrast medium except mild rash
- Currently pregnant or breastfeeding
- Known dementia or psychiatric disease preventing neurological assessment and follow-up
- Life expectancy less than 3 months
- Participation in another drug or device trial currently or expected within 3 months
- Any other condition deemed inappropriate for participation by the site investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
X
Xu Tong, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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