Study of Gonioscopy Assisted Transluminal Trabeculotomy Safety and Effectiveness in Patients 40 and Older with Primary Open-angle Glaucoma and Cataract Undergoing Cataract Surgery

What this Trial Is About

Researchers are evaluating the intraocular pressure IOP changes in patients with mild or moderate primary open-angle glaucoma OAG who also have cataracts. This clinical trial compares three groups of patients treated with one or more hypotensive medications or those with IOP between 20 mmHg and 26 mmHg. The study aims to assess differences in medication use, reoperation rates, side effects, vision quality, endothelial cell loss, astigmatism, and quality of life changes after surgery over a two-year follow-up period. Participants are assigned to one of three groups those undergoing cataract surgery combined with 360 gonioscopy assisted transluminal trabeculotomy GATT, those with cataract surgery combined with 180 GATT, and those undergoing cataract surgery alone. The GATT procedures involve opening the Schlemm Canal using a polypropylene suture through the trabecular meshwork. All treatments are delivered as surgical procedures during cataract surgery. Throughout the two-year study, participants will be monitored regularly for changes in intraocular pressure and the number of glaucoma medications used, starting from medication washout until two years post-surgery. Researchers will also evaluate prognostic factors, secondary eye changes, visual acuity, and quality of life. Safety and adverse effects will be tracked during this period to understand the impact of these surgical interventions on glaucoma and cataract management.

Efficacy and Safety of Gonioscopy Assisted Transluminal Trabeculotomy in Patients with Primary Open-angle Glaucoma and Cataract.