Actively Recruiting
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Anterior Circulation Large Vessel Occlusion Stroke -2
Led by Capital Medical University · Updated on 2026-05-12
692
Participants Needed
53
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a randomized, double-blind, placebo-controlled clinical trial. Investigators aim to assess the efficacy and safety of interleukin-6 receptor inhibitor combined with endovascular treatment in patients with acute anterior circulation large vessel occlusion stroke.
CONDITIONS
Official Title
Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Anterior Circulation Large Vessel Occlusion Stroke -2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or greater, male or female;
- Acute ischemic stroke caused by occlusion of intracranial segment of the internal carotid artery, middle cerebral artery M1 or proximal/dominant M2 segment;
- Decided to undergo emergency endovascular treatment;
- Time from stroke onset to arterial puncture within 24 hours;
- National Institutes of Health Stroke Scale (NIHSS) score ≥ 6;
- Signed informed consent from the patients or the legally authorized representatives.
You will not qualify if you...
- Intracerebral hemorrhage, epidural hematoma, subdural hematoma, intraventricular hemorrhage, or subarachnoid hemorrhage;
- Pre-stroke modified Rankin scale (mRS) score >1;
- Known allergy to tocilizumab or excipients;
- Known allergy to iodinated contrast agents;
- Anticipated difficulty in completing endovascular treatment due to vascular tortuosity;
- History of congenital or acquired bleeding disorders, coagulation factor deficiency diseases, or thrombocytopenic diseases;
- Systolic blood pressure ≥180mmHg or diastolic blood pressure ≥110mmHg despite blood pressure control;
- Neutrophils <2×109 /L;
- Platelets <100×109 /L;
- Blood glucose <2.8mmol/L (50 mg/dL) or >22.2mmol/L (400 mg/dL);
- Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels >2 times the upper limit of normal;
- Known recent or current serum creatinine >2 times the upper limit of normal or estimated glomerular filtration rate (eGFR) <60 mL/min;
- Pregnant, lactating, or planning pregnancy within 90 days;
- Severe mental disorders or inability to comply with informed consent and follow-up requirements due to dementia;
- Concurrent malignant tumors or severe systemic diseases with expected survival of less than 90 days;
- Presence of autoimmune diseases or use of immunosuppressive drugs;
- Systemic infectious diseases;
- Participation in another interventional clinical study within 30 days before randomization or currently participating in another interventional clinical study;
- Considered by the investigator to have other conditions that might affect compliance or preclude participation in this study.
AI-Screening
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Trial Site Locations
Total: 53 locations
1
Si Country People's Hospital
Suzhou, Anhui, China
Actively Recruiting
2
Suixi County Hospital
Suzhou, Anhui, China
Actively Recruiting
3
Suzhou Hospital of Anhui Medical University
Suzhou, Anhui, China
Actively Recruiting
4
Zhangzhou Municipal Hospital
Zhangzhou, Fujian, China
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5
Lingshan County People's Hospital
Qinzhou, Guangxi, China
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6
JingDong ZhongMei Hospital
Langfang, Hebei, China
Actively Recruiting
7
The second Hospital of Qinhuangdao
Qinhuangdao, Hebei, China
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8
Tangshan Workers Hospital
Tangshan, Hebei, China
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9
Yutian Hospital
Tangshan, Hebei, China
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10
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
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11
The People's Hospital of Anyang
Anyang, Henan, China
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12
Jun County People's Hospital
Hebi, Henan, China
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13
Jiaozuo No.2 People's Hospital
Jiaozuo, Henan, China
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14
Luoyang Central Hospital
Luoyang, Henan, China
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15
Mengjin County People's Hospital
Luoyang, Henan, China
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16
Nanyang Central Hospital
Nanyang, Henan, China
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17
Nanyang Nanshi Hospital
Nanyang, Henan, China
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18
Nanyang Second People's Hospital
Nanyang, Henan, China
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19
Tanghe County People's Hospital
Nanyang, Henan, China
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20
Puyang Oilfield General Hospital
Puyang, Henan, China
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21
Ningling County People's Hospital
Shangqiu, Henan, China
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22
Shangqiu No.1 People's Hospital
Shangqiu, Henan, China
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23
Huixian People's Hospital
Xinxiang, Henan, China
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24
The First Affiliated Hospital of Henan Medical University
Xinxiang, Henan, China
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25
Xinxiang Central Hospital
Xinxiang, Henan, China
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26
Henan Provincial People's Hospital
Zhengzhou, Henan, China
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27
Xihua County People's Hospital
Zhoukou, Henan, China
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28
Tianyou Hospital Affliated to Wuhan University of Science &Technology
Wuhan, Hubei, China
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29
Xiangyang No.1 People's hospital
Xiangyang, Hubei, China
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30
Xing'an league People's Hospital
Xing’an, Inner Mongolia, China
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31
Nantong First People's Hospital
Nantong, Jiangsu, China
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32
Binzhou Medical University Hospital
Binzhou, Shandong, China
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33
People's Hospital of Dongying
Dongying, Shandong, China
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34
Linshu Country People's Hospital
Linyi, Shandong, China
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35
Linyi People's Hospital
Linyi, Shandong, China
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36
Qingdao Huangdao District Hospital of Traditional Chinese Medicine
Qingdao, Shandong, China
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37
Yiyuan Country People's Hospital
Zibo, Shandong, China
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38
Zibo Central Hospital
Zibo, Shandong, China
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39
Jincheng People's Hospital
Jincheng, Shanxi, China
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40
Shanxi Bethune Hospital
Taiyuan, Shanxi, China
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41
Shanxi Medical University First Hospital
Taiyuan, Shanxi, China
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42
The People's Hospital of Xianyang
Xianyang, Shanxi, China
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43
Daliuta Experimental District People's Hospital of Shenmu City
Yulin, Shanxi, China
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44
Zhongxiang Traditional Chinese Medical Hospital
Zhongxiang, Wuhan, China
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45
Jiaxing First Hospital
Jiaxing, Zhejiang, China
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46
Lishui Central Hospital
Lishui, Zhejiang, China
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47
Ningbo Medical Center Lihuili Hospital
Ningbo, Zhejiang, China
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48
Ningbo NO.2 Hospital
Ningbo, Zhejiang, China
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49
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Taizhou, Zhejiang, China
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50
Wenzhou People's Hospital
Wenzhou, Zhejiang, China
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51
Yueqing People's Hospital
Yueqing, Zhejiang, China
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52
Xuanwu Hospital, Capital Medical University
Beijing, China, 100053
Actively Recruiting
53
Beijing Red Cross Emergency Medical Center
Beijing, China
Actively Recruiting
Research Team
X
Xunming Ji, PhD/MD
CONTACT
C
Chuanjie Wu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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