Study of Frozen Versus Fresh Platelet-Rich Plasma Injections for Treating Knee Osteoarthritis in Adults Aged 40 to 85

What this Trial Is About

Researchers are evaluating the use of intra-articular injections of platelet-rich plasma PRP in patients with knee osteoarthritis. The study compares frozen-stored PRP injections to fresh PRP injections applied at the time of collection. This randomized, double-blind trial aims to assess the efficacy and safety of these treatments in adults aged 40 to 85 years diagnosed with knee osteoarthritis. Participants receive either frozen platelet-rich plasma or fresh platelet-rich plasma injected into the knee joint. The treatments are administered according to a randomized assignment, maintaining blinding for both participants and researchers. The study is conducted by MiKS Hospital and includes follow-up evaluations to monitor outcomes over several months. During the study, participants will undergo assessments including the Knee Injury and Osteoarthritis Outcome Score KOOS at 2 and 6 months, the Visual Analog Scale VAS for pain at 2 and 6 months, and the Lequesne Index at both time points. These measures help evaluate pain, function, and severity of osteoarthritis. Participants will be monitored for safety and adherence throughout the follow-up period, which extends up to 6 months after treatment.

Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis