Actively Recruiting
The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery
Led by Beijing Tiantan Hospital · Updated on 2026-03-06
134
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy. It is reported that the incidence of acute pain following VATS exceeds 80%. Inadequate postoperative analgesia may trigger a series of adverse physiological stress responses, increase the occurrence of postoperative complications, and affect the rehabilitation process.If acute pain is not managed promptly and sufficiently, nearly one-quarter of patients may develop chronic pain, impacting normal life and sleep quality after discharge.In recent years, multimodal postoperative analgesia protocols have been increasingly adopted in clinical practice. The Rhomboid intercostal block (RIB), as a novel regional anesthesia technique within the multimodal analgesia framework, has been widely utilized in various thoracic surgical procedures. Liposomal bupivacaine, an innovative long-acting sustained-release amide local anesthetic, provides prolonged analgesia for up to 72 hours. However, its efficacy and safety in video-assisted thoracoscopic surgery (VATS) have not yet been fully validated. Based on this premise, the present study aims to evaluate and compare the clinical outcomes of ultrasound-guided Rhomboid intercostal block (RIB) utilizing liposomal bupivacaine combined with conventional bupivacaine for postoperative pain management in patients undergoing VATS.
CONDITIONS
Official Title
The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for elective video-assisted thoracoscopic lobectomy or wedge resection under general anesthesia
- Ages 18 to 64 years old
- American Society of Anesthesiologists (ASA) physical status of I-III
- Glasgow Coma Scale (GCS) score of 15
- Able to understand the clinical trial and sign informed consent
You will not qualify if you...
- History of chronic pain syndrome of any cause
- Heart conduction block (sinus block or atrioventricular block)
- Unstable coronary artery disease
- Gastric ulcer or gastric bleeding
- Diabetes treated with insulin
- Coagulation dysfunction or taking oral anticoagulants not stopped before surgery
- Abnormal liver function (ALT/AST > 2x upper limit or total bilirubin ≥ 1.5x upper limit)
- Renal impairment (serum creatinine > 176 µmol/L) or dialysis within 28 days before surgery
- History of mental illness or current psychotropic medication
- Excessive alcohol or drug abuse, chronic opioid use, or recent use of sedatives, analgesics, or painkillers
- Pregnancy or breastfeeding
- Extreme body mass index (BMI < 15 or > 35)
- Participation in interfering interventional trial
- History of allergy to local anesthetics or study drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
F
Fang Luo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here