Study of Liposomal Bupivacaine and Bupivacaine for Pain Relief After Laparoscopic Surgery A Randomized Trial Using Ultrasound-Guided Transversus Abdominis Plane Block

What this Trial Is About

Laparoscopic surgery is commonly chosen for abdominal procedures because it is less invasive, allows quicker recovery, and has fewer complications. However, many patients still experience postoperative pain, which can delay recovery and may develop into chronic pain without proper management. While opioids are effective for pain relief, their side effects limit their use after minimally invasive surgeries. This research evaluates the use of ultrasound-guided transversus abdominis plane block TAPB with liposomal bupivacaine, a longer-acting local anesthetic, to improve pain control after laparoscopic surgery. The study compares two groups of patients undergoing laparoscopic surgery. One group receives a TAPB using bupivacaine hydrochloride, while the other group receives a TAPB with a combination of liposomal bupivacaine and bupivacaine. Both groups receive patient-controlled analgesia pumps with sufentanil and ondansetron postoperatively. Additional pain medications like oxycodone-acetaminophen tablets or intravenous morphine may be given if needed. The injections are performed before the surgical incision using ultrasound guidance. Participants will be monitored for pain levels at rest and during movement at multiple time points up to three months after surgery. Researchers will track the use of rescue pain medications, patient satisfaction, sedation levels, recovery quality, and any side effects or complications. Other assessments include length of hospital stay and total costs. The primary outcome is the amount of intravenous morphine equivalents used within 48 hours after surgery. The study aims to provide detailed information about pain relief effectiveness and safety of liposomal bupivacaine in laparoscopic surgery patients.

The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery