Actively Recruiting
Led by Beijing Tiantan Hospital · Updated on 2026-03-17
318
Participants Needed
1
Research Sites
13 weeks
Total Duration
Laparoscopic surgery is commonly chosen for abdominal procedures because it is less invasive, allows quicker recovery, and has fewer complications. However, many patients still experience postoperative pain, which can delay recovery and may develop into chronic pain without proper management. While opioids are effective for pain relief, their side effects limit their use after minimally invasive surgeries. This research evaluates the use of ultrasound-guided transversus abdominis plane block (TAPB) with liposomal bupivacaine, a longer-acting local anesthetic, to improve pain control after laparoscopic surgery. The study compares two groups of patients undergoing laparoscopic surgery. One group receives a TAPB using bupivacaine hydrochloride, while the other group receives a TAPB with a combination of liposomal bupivacaine and bupivacaine. Both groups receive patient-controlled analgesia pumps with sufentanil and ondansetron postoperatively. Additional pain medications like oxycodone-acetaminophen tablets or intravenous morphine may be given if needed. The injections are performed before the surgical incision using ultrasound guidance. Participants will be monitored for pain levels at rest and during movement at multiple time points up to three months after surgery. Researchers will track the use of rescue pain medications, patient satisfaction, sedation levels, recovery quality, and any side effects or complications. Other assessments include length of hospital stay and total costs. The primary outcome is the amount of intravenous morphine equivalents used within 48 hours after surgery. The study aims to provide detailed information about pain relief effectiveness and safety of liposomal bupivacaine in laparoscopic surgery patients.
CONDITIONS
The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 48 hours postoperatively
Participants undergo laparoscopic surgery with a transverse abdominis plane block using either liposomal bupivacaine plus bupivacaine or bupivacaine hydrochloride to manage postoperative pain. Postoperative pain is managed with patient-controlled analgesia and additional medications as needed.
1 surgical visit and postoperative monitoring up to 48 hours
Duration - 3 months
Participants are followed for additional assessments of pain, recovery, and any adverse events up to 3 months after surgery.
Visits at 1 week, 1 month, and 3 months postoperatively
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
F
Fang Luo
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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