Actively Recruiting
Efficacy and Safety of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study
Led by First Affiliated Hospital of Chongqing Medical University · Updated on 2026-02-04
45
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to assess the feasibility, safety, acceptability, and preliminary efficacy trends of a Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) intervention for adolescent depression through a pilot clinical trial. The findings will inform the design and optimization of subsequent formal randomized controlled trials, providing essential evidence for their execution.
CONDITIONS
Official Title
Efficacy and Safety of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 12 to 18 years
- Diagnosis of major depressive disorder (MDD) in a current depressive episode confirmed by DSM-5 and K-SADS-PL
- Children's Depression Rating Scale (CDRS-R) score of 40 or higher
- Stable psychiatric medication use for at least 4 weeks before enrollment and continuation during the study
You will not qualify if you...
- Presence of psychiatric disorders other than anxiety
- Depression with psychotic symptoms
- Young Mania Rating Scale (YMRS) score greater than 13
- History of neurological disorders or severe physical illnesses such as epilepsy, brain injury, thyroid disorders, lupus, diabetes, pulmonary, hepatic, or renal impairment, or major trauma
- Current use of anticonvulsants or high-dose benzodiazepines
- Previous treatments with electroconvulsive therapy, TMS, tDCS, tACS, or other neuromodulation
- History of alcohol or substance abuse or dependence
- Pregnancy or breastfeeding in women
- High suicide risk at present
- Scalp conditions or perforations affecting magnetic stimulation delivery
- Contraindications to MRI
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Actively Recruiting
Research Team
X
Xinyu Zhou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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