Actively Recruiting
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
Led by First Affiliated Hospital of Zhejiang University · Updated on 2024-12-30
488
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Zhejiang University
Lead Sponsor
Y
Yuyao People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate whether methylene blue injection can safely and effectively improve the survival rate of patients with severe septic shock, shorten the duration of norepinephrine use, reduce the dosage of vasopressors, promptly correct hemodynamics, and improve tissue perfusion and organ function impairment.
CONDITIONS
Official Title
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of septic shock meeting Sepsis 3.0 criteria requiring vasopressor therapy to maintain mean arterial pressure ≥ 65 mmHg with blood lactate > 2 mmol/L
- Started norepinephrine treatment within 24 hours of septic shock diagnosis
- Requires norepinephrine dose of at least 0.1 µg/kg/min to maintain mean arterial pressure ≥ 65 mmHg
You will not qualify if you...
- Pregnant or breastfeeding women
- Allergic to methylene blue or its injection components
- Personal or family history of glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Expected survival time less than 48 hours
- On norepinephrine treatment for more than 24 hours
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
W
Wenqiao Yu, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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