Actively Recruiting
Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage
Led by Beijing Tiantan Hospital · Updated on 2026-04-23
1192
Participants Needed
41
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. It aims to evaluate the efficacy and safety of oral minocycline in patients with acute spontaneous intracerebral hemorrhage within 48 hours of onset.
CONDITIONS
Official Title
Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- CT-confirmed spontaneous supratentorial intracerebral hemorrhage
- Age between 18 and 80 years
- Within 48 hours of symptom onset
- Hematoma volume between 15 and 40 ml
- NIHSS score between 8 and 24, with item 1a less than or equal to 2
- Signed informed consent by the patient or legal representative
You will not qualify if you...
- Secondary intracerebral hemorrhage due to trauma, tumor, vascular malformation, aneurysm, coagulation disorder, or other causes
- Intraventricular hemorrhage filling one entire lateral ventricle, third ventricle, or fourth ventricle, or more than half of two lateral ventricles
- Significant subarachnoid hemorrhage (Fisher grade 3 or higher) or subdural hemorrhage
- Uncontrollable hypertension with systolic blood pressure persistently 180 mmHg or higher despite intensive treatment
- Progressive neurological or severe systemic diseases
- Planned surgical intervention for intracerebral hemorrhage
- Pre-stroke disability with modified Rankin Scale score greater than 1
- Severe cardiac insufficiency (NYHA Class III-IV), severe liver or renal disease, or malignancy with life expectancy less than 1 year
- Moderate to severe anemia, thrombocytopenia, leukopenia, or coagulopathy
- Allergy or intolerance to minocycline or other tetracycline antibiotics
- History of pseudomembranous enteritis or antibiotic-associated enteritis
- Use of tetracycline antibiotics within the past week
- Intracranial or spinal surgery within the past 3 months
- Major surgery or severe physical trauma within the past month
- Females who are pregnant, within 30 days postpartum, or breastfeeding
- Participation in other interventional clinical trials within the past 3 months
- Inability to provide informed consent
- Mental, cognitive, emotional, or physical disorders preventing understanding or following study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 41 locations
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
2
Chongqing Tongnan District People's Hospital
Chongqing, Chongqing Municipality, China
Actively Recruiting
3
The Second People's Hospital of Guangdong Province
Guangzhou, Guangdong, China
Actively Recruiting
4
Baoding Fourth Central Hospital (Tangxian, Hebei)
Baoding, Hebei, China
Actively Recruiting
5
Zhangjiakou First Hospital
Zhangjiakou, Hebei, China
Not Yet Recruiting
6
Zunhua People's Hospital
Zunhua, Hebei, China
Actively Recruiting
7
Mengzhou Fuxing Hospital
Mengzhou, Henan, China
Actively Recruiting
8
Nanle County People's Hospital
Nanle, Henan, China
Actively Recruiting
9
Neixiang County People's Hospital
Neixiang, Henan, China
Actively Recruiting
10
General Hospital of Pingmei Shenma Medical Group
Pingdingshan, Henan, China
Actively Recruiting
11
Puyang County People's Hospital
Puyang, Henan, China
Actively Recruiting
12
Yellow River Sanmenxia Hospital
Sanmenxia, Henan, China
Actively Recruiting
13
Shangqiu Third People's Hospital
Shangqiu, Henan, China
Actively Recruiting
14
Suixian Hospital of Traditional Chinese Medicine
Shangqiu, Henan, China
Actively Recruiting
15
Taikang County People's Hospital
Taikang Chengguanzhen, Henan, China
Actively Recruiting
16
Henan Sanbo Brain Hospital
Zhengzhou, Henan, China
Actively Recruiting
17
Taihe Hospital of Shiyan
Shiyan, Hubei, China
Actively Recruiting
18
Liuyang Jili Hospital
Guankou, Hunan, China
Actively Recruiting
19
Shaodong People's Hospital
Shaodong, Hunan, China
Actively Recruiting
20
Baotou Central Hospital
Baotou, Inner Mongolia, China
Actively Recruiting
21
People's Hospital of Inner Mongolia Autonomous Region
Hohhot, Inner Mongolia, China
Actively Recruiting
22
Ordos Central Hospital
Ordos, Inner Mongolia, China
Actively Recruiting
23
Ulanqab Central Hospital
Ulanqab, Inner Mongolia, China
Actively Recruiting
24
Wuyuan County People's Hospital
Wuyuan, Inner Mongolia, China
Actively Recruiting
25
Affiliated Hospital of Nantong University
Nantong, Jiangsu, China
Actively Recruiting
26
Siyang Kangda Hospital
Siyang, Jiangsu, China
Actively Recruiting
27
Dalian Lushunkou District Hospital of Traditional Chinese Medicine
Dalian, Liaoning, China
Actively Recruiting
28
Kuandian Central Hospital
Dandong, Liaoning, China
Actively Recruiting
29
Yingkou Fangda Hospital
Yingkou, Liaoning, China
Actively Recruiting
30
The Fifth People's Hospital of Ningxia Hui Autonomous Region
Shizuishan, Ningxia, China
Actively Recruiting
31
Xianyang Hospital of Yan'an University
Xianyang, Shaanxi, China
Actively Recruiting
32
Binzhou Central Hospital, Shandong Province
Binzhou, Shandong, China
Actively Recruiting
33
Third People's Hospital of Liaocheng City, Shandong Province
Liaocheng, Shandong, China
Actively Recruiting
34
Weihai Wendeng District People's Hospital
Tianfu, Shandong, China
Actively Recruiting
35
Weihai Municipal Hospital
Weihai, Shandong, China
Actively Recruiting
36
Weihai Municipal Third Hospital
Weihai, Shandong, China
Actively Recruiting
37
451560995@Qq.Com
Shanghai, Shanghai Municipality, China
Actively Recruiting
38
Yilong County People's Hospital
Jincheng, Sichuan, China
Actively Recruiting
39
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China
Actively Recruiting
40
Yiyang Central Hospital
Hunan, Yiyang, China
Actively Recruiting
41
Ningbo Second Hospital
Ningbo, Zhejiang, China
Actively Recruiting
Research Team
K
Kaijiang Kang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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