Actively Recruiting
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-11
490
Participants Needed
121
Research Sites
404 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety and efficacy of nemtabrutinib (formerly ARQ 531) in participants with hematologic malignancies of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), Richter's transformation, marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and Waldenström's macroglobulinemia (WM).
CONDITIONS
Official Title
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have an ECOG performance status of 0 to 2 within 7 days before starting treatment
- Have a life expectancy of at least 3 months
- Able to swallow and keep oral medication
- Hepatitis B surface antigen positive participants must have received antiviral therapy for at least 4 weeks with undetectable viral load
- Participants with past Hepatitis C infection must have undetectable viral load at screening
- Have adequate organ function
- Male participants must agree to avoid sperm donation and use contraception or abstain from penile-vaginal intercourse during and after treatment
- Female participants not pregnant or breastfeeding and not of childbearing potential or using highly effective contraception or abstaining from penile-vaginal intercourse during and after treatment
- Participants with HIV must have CD4 count >350 cells/uL, undetectable viral load, stable ART for at least 4 weeks, and compliance with ART
- Confirmed diagnosis of CLL/SLL with at least 2 prior therapies (Part 1) or meet specific criteria for Cohorts A, B, C, or J in Part 2
- Active disease requiring therapy for CLL/SLL
- For SLL in Part 2, have evaluable lymph node biopsy or bone marrow aspirate for biomarker analysis
- Confirmed diagnosis of Richter's transformation, MCL, MZL, FL, or WM with defined prior therapy and measurable disease
- Measurable disease with at least 1 lesion measurable by CT scan
- Provide lymph node biopsy or bone marrow aspirate for biomarker analysis as required by cohort
You will not qualify if you...
- Have active Hepatitis B or C infection
- History of malignancy within 3 years except certain skin cancers, carcinoma in situ, or low-risk early-stage prostate cancer
- Active central nervous system disease
- Active infection requiring systemic therapy
- Received systemic anti-cancer therapy within 5 half-lives or 4 weeks before starting study treatment
- Participated in another investigational study or used an investigational device within 4 weeks before starting treatment
- Have clinically significant gastrointestinal problems affecting absorption
- History of severe bleeding disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 121 locations
1
Highlands Oncology Group ( Site 2728)
Springdale, Arkansas, United States, 72762
Actively Recruiting
2
University of California San Diego Moores Cancer Center ( Site 2717)
La Jolla, California, United States, 92093-0698
Actively Recruiting
3
Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724)
Torrance, California, United States, 90502
Completed
4
Colorado Blood Cancer Institute ( Site 2726)
Denver, Colorado, United States, 80218
Actively Recruiting
5
The University of Louisville, James Graham Brown Cancer Center ( Site 2729)
Louisville, Kentucky, United States, 40202
Completed
6
Mayo Clinic - Rochester ( Site 2706)
Rochester, Minnesota, United States, 55905
Active, Not Recruiting
7
Astera Cancer Care ( Site 2732)
East Brunswick, New Jersey, United States, 08816
Actively Recruiting
8
John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704)
Hackensack, New Jersey, United States, 07601
Actively Recruiting
9
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708)
Fargo, North Dakota, United States, 58102
Completed
10
UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730)
Dallas, Texas, United States, 75390
Actively Recruiting
11
Medical Oncology Associates (Summit Cancer Centers) ( Site 2710)
Spokane, Washington, United States, 99208
Actively Recruiting
12
Hospital Aleman ( Site 0102)
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1118AAT
Actively Recruiting
13
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103)
Buenos Aires, Buenos Aires F.D., Argentina, C1431FWO
Actively Recruiting
14
Fundacion Estudios Clinicos ( Site 0112)
Rosario, Santa Fe Province, Argentina, S2000DEJ
Actively Recruiting
15
FUNDALEU ( Site 0104)
Caba, Argentina, C1114AAN
Actively Recruiting
16
Hospital Privado Universitario de Córdoba ( Site 0107)
Córdoba, Argentina, X5016KEH
Actively Recruiting
17
Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110)
Mendoza, Argentina, M5500AYB
Completed
18
Nepean Hospital-Nepean Cancer Care Centre ( Site 0204)
Sydney, New South Wales, Australia, 2747
Completed
19
Box Hill Hospital ( Site 0203)
Box Hill, Victoria, Australia, 3128
Actively Recruiting
20
Sir Charles Gairdner Hospital ( Site 0200)
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
21
Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303)
São Paulo, São Paulo, Brazil, 05403-000
Actively Recruiting
22
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300)
Rio de Janeiro, Brazil, 20231-050
Actively Recruiting
23
BP - A Beneficencia Portuguesa de São Paulo ( Site 0302)
São Paulo, Brazil, 01321-001
Completed
24
Hospital Paulistano - Amil Clinical Research ( Site 0311)
São Paulo, Brazil, 01321-001
Actively Recruiting
25
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401)
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
26
The Ottawa Hospital ( Site 0404)
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
27
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0406)
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
28
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0403)
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
29
Jewish General Hospital ( Site 0400)
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
30
Anhui Provincial Hospital ( Site 2808)
Hefei, Anhui, China, 230071
Actively Recruiting
31
Peking University Third Hospital-Hematology ( Site 2827)
Beijing, Beijing Municipality, China, 100191
Actively Recruiting
32
The Second Affiliated Hospital of Chongqing Medical University ( Site 2825)
Chongqing, Chongqing Municipality, China, 400072
Completed
33
Sun Yat-sen University Cancer Center-Internal Medicine ( Site 2824)
Guangzhou, Guangdong, China, 510060
Actively Recruiting
34
Liuzhou People's Hospital ( Site 2817)
Liuzhou, Guangxi, China, 545006
Actively Recruiting
35
Guangxi Medical University Cancer Hospital ( Site 2814)
Nanning, Guangxi, China, 530028
Actively Recruiting
36
Henan Cancer Hospital-hematology department ( Site 2802)
Zhengzhou, Henan, China, 450008
Actively Recruiting
37
Wuhan Union Hospital ( Site 2816)
Wuhan, Hubei, China, 430022
Actively Recruiting
38
The Second Xiangya Hospital of Central South University ( Site 2820)
Changsha, Hunan, China, 410011
Actively Recruiting
39
Hunan Cancer Hospital ( Site 2822)
Changsha, Hunan, China, 410013
Actively Recruiting
40
Jiangsu Province Hospital ( Site 2823)
Nanjing, Jiangsu, China, 210029
Actively Recruiting
41
The Affiliated Hospital of Xuzhou Medical College ( Site 2818)
Xuzhou, Jiangsu, China, 221000
Completed
42
The First Affiliated Hospital of Nanchang University ( Site 2815)
Nanchang, Jiangxi, China, 330006
Actively Recruiting
43
The First Hospital of Jilin University-Hematology ( Site 2803)
Changchun, Jilin, China, 130021
Actively Recruiting
44
Fudan University Shanghai Cancer Center ( Site 2801)
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
45
Huashan Hospital, Fudan University ( Site 2821)
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
46
West China Hospital Sichuan University ( Site 2810)
Chengdu, Sichuan, China, 610041
Actively Recruiting
47
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Unio ( Site 2800)
Tianjin, Tianjin Municipality, China, 301617
Actively Recruiting
48
The First Affiliated Hospital, Zhejiang University ( Site 2826)
Hangzhou, Zhejiang, China, 310002
Actively Recruiting
49
Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0600)
Brno, Brno-mesto, Czechia, 625 00
Actively Recruiting
50
Fakultni nemocnice Hradec Kralove ( Site 0601)
Hradec Králové, Czechia, 500 05
Actively Recruiting
51
Aarhus University Hospital ( Site 0702)
Aarhus N, Central Jutland, Denmark, 8200
Completed
52
Aalborg Universitetshospital ( Site 0703)
Aalborg, North Denmark, Denmark, 9000
Actively Recruiting
53
Sjaellands Universitetshospital Roskilde ( Site 0701)
Roskilde, Region Sjælland, Denmark, 4000
Actively Recruiting
54
Odense University Hospital ( Site 0705)
Odense C, Region Syddanmark, Denmark, 5000
Completed
55
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0810)
Nice, Alpes-Maritimes, France, 06202
Actively Recruiting
56
Centre Hospitalier Lyon-Sud ( Site 0804)
Pierre-Bénite, Auvergne-Rhône-Alpes, France, 69495
Actively Recruiting
57
Institut Paoli-Calmettes ( Site 0803)
Marseille, Bouches-du-Rhone, France, 13009
Actively Recruiting
58
Centre Hospitalier de Versailles ( Site 0809)
Le Chesnay, Yvelines, France, 78150
Completed
59
Hopital Saint Louis ( Site 0805)
Paris, France, 75010
Actively Recruiting
60
Universitaetsklinikum Ulm. ( Site 0906)
Ulm, Baden-Wurttemberg, Germany, 89081
Actively Recruiting
61
Universitaetsklinikum Koeln ( Site 0901)
Cologne, North Rhine-Westphalia, Germany, 50937
Actively Recruiting
62
St. Marien-Krankenhaus Siegen ( Site 0914)
Siegen, North Rhine-Westphalia, Germany, 57072
Completed
63
Universitaetsklinikum Carl Gustav Carus ( Site 0902)
Dresden, Saxony, Germany, 01307
Actively Recruiting
64
Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar ( Site 1202)
Pécs, Baranya, Hungary, 7624
Actively Recruiting
65
Debreceni Egyetem Klinikai Kozpont ( Site 1201)
Debrecen, Hajdú-Bihar, Hungary, 4032
Actively Recruiting
66
Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1206)
Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary, 4400
Actively Recruiting
67
Orszagos Onkologiai Intezet ( Site 1200)
Budapest, Hungary, 1122
Actively Recruiting
68
Beaumont Hospital ( Site 2900)
Dublin, Ireland, Dublin 9
Actively Recruiting
69
University Hospital Limerick ( Site 2903)
Limerick, Ireland, V94 F858
Actively Recruiting
70
Ha Emek Medical Center ( Site 1305)
Afula, Israel, 1834111
Actively Recruiting
71
Soroka Medical Center ( Site 1307)
Beersheba, Israel, 8457108
Actively Recruiting
72
Rambam Medical Center ( Site 1301)
Haifa, Israel, 3109601
Actively Recruiting
73
Hadassah Ein Karem Jerusalem ( Site 1300)
Jerusalem, Israel, 9112001
Actively Recruiting
74
Chaim Sheba Medical Center ( Site 1302)
Ramat Gan, Israel, 5262001
Actively Recruiting
75
Kaplan Medical Center ( Site 1304)
Rehovot, Israel, 76100
Actively Recruiting
76
Sourasky Medical Center ( Site 1303)
Tel Aviv, Israel, 6423906
Actively Recruiting
77
Istituto Tumori Giovanni Paolo II ( Site 1409)
Bari, Italy, 70124
Actively Recruiting
78
A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 1400)
Bologna, Italy, 40138
Actively Recruiting
79
ASST Spedali Civili di Brescia ( Site 1408)
Brescia, Italy, 25123
Actively Recruiting
80
IRCCS Ospedale San Raffaele ( Site 1402)
Milan, Italy, 20132
Actively Recruiting
81
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1403)
Naples, Italy, 80131
Actively Recruiting
82
Fondazione IRCCS Policlinico San Matteo ( Site 1407)
Pavia, Italy, 27100
Actively Recruiting
83
IRCCS - Arcispedale Santa Maria Nuova ( Site 1405)
Reggio Emilia, Italy, 42123
Actively Recruiting
84
Policlinico Umberto I ( Site 1404)
Roma, Italy, 00161
Completed
85
Pratia MCM Krakow ( Site 1601)
Krakow, Lesser Poland Voivodeship, Poland, 30-727
Actively Recruiting
86
Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site 1606)
Wroclaw, Lower Silesian Voivodeship, Poland, 50-367
Actively Recruiting
87
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1608)
Warsaw, Masovian Voivodeship, Poland, 02-781
Actively Recruiting
88
Szpital Wojewódzki w Opolu-Hematology Department ( Site 1607)
Opole, Opole Voivodeship, Poland, 45-061
Completed
89
Szpitale Pomorskie Sp. z o.o. ( Site 1600)
Gdynia, Pomeranian Voivodeship, Poland, 81-519
Completed
90
Spitalul Clinic Colțea ( Site 1805)
Bucharest, Bucharest, Romania, 030171
Actively Recruiting
91
Ovidius Clinical Hospital ( Site 1804)
Ovidiu, Constanța County, Romania, 905900
Completed
92
Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 1802)
Brasov, Romania, 500052
Actively Recruiting
93
Institutul Regional de Oncologie Iasi ( Site 1801)
Iași, Romania, 700483
Actively Recruiting
94
Severance Hospital Yonsei University Health System ( Site 2201)
Seoul, South Korea, 03722
Actively Recruiting
95
Samsung Medical Center ( Site 2200)
Seoul, South Korea, 06351
Actively Recruiting
96
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 2000)
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Actively Recruiting
97
Hospital Universitario de Salamanca ( Site 2002)
Salamanca, Castille and León, Spain, 37007
Actively Recruiting
98
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2005)
A Coruña, La Coruna, Spain, 15006
Actively Recruiting
99
Hospital General Universitario de Alicante ( Site 2007)
Alicante, Spain, 03010
Actively Recruiting
100
Hospital Universitari Vall d'Hebron ( Site 2001)
Barcelona, Spain, 08035
Actively Recruiting
101
Hospital Universitario 12 de Octubre ( Site 2003)
Madrid, Spain, 28041
Actively Recruiting
102
Hospital Puerta de Hierro ( Site 2009)
Madrid, Spain, 28222
Actively Recruiting
103
Inselspital Bern ( Site 2303)
Bern, Canton of Bern, Switzerland, 3010
Actively Recruiting
104
Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 2302)
Bellinzona, Canton Ticino, Switzerland, 6500
Actively Recruiting
105
Mega Medipol-Hematology ( Site 2406)
Stanbul, Istanbul, Turkey (Türkiye), 34214
Active, Not Recruiting
106
Ankara Universitesi Tip Fakultesi Cebeci Hastanesi ( Site 2400)
Ankara, Turkey (Türkiye), 06590
Actively Recruiting
107
VKV Amerikan Hastanesi ( Site 2403)
Istanbul, Turkey (Türkiye), 34365
Completed
108
Sisli Florence Nightingale Hastanesi ( Site 2407)
Istanbul, Turkey (Türkiye), 34381
Actively Recruiting
109
Dokuz Eylül Üniversitesi-Hematology ( Site 2402)
Izmir, Turkey (Türkiye), 35340
Active, Not Recruiting
110
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2509)
Cherkassy, Cherkasy Oblast, Ukraine, 18009
Active, Not Recruiting
111
Communal non-profit enterprise "Regional clinical hospital o-Hematology Department ( Site 2510)
Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76008
Completed
112
Instit. of Blood Transfusion Medicine of the National Academy ( Site 2506)
Lviv, Lviv Oblast, Ukraine, 79044
Actively Recruiting
113
National Cancer Institute ( Site 2507)
Kyiv, Ukraine, 03022
Actively Recruiting
114
Bristol Haematology and Oncology Centre ( Site 2610)
Bristol, Bristol, City of, United Kingdom, BS2 8ED
Actively Recruiting
115
Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601)
Nottingham, England, United Kingdom, NG5 1PF
Actively Recruiting
116
GenesisCare - Windsor ( Site 2608)
Windsor, England, United Kingdom, SL4 3HD
Actively Recruiting
117
Sarah Cannon Research Institute UK ( Site 2612)
London, London, City of, United Kingdom, W1G 6AD
Actively Recruiting
118
GenesisCare - Oxford ( Site 2607)
Oxford, Oxfordshire, United Kingdom, OX4 6LB
Actively Recruiting
119
GenesisCare - Cambridge ( Site 2611)
Newmarket, Suffolk, United Kingdom, CB8 7XN
Actively Recruiting
120
The Royal Marsden NHS Foundation Trust. ( Site 2606)
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
121
The Christie NHS Foundation Trust ( Site 2602)
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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