Actively Recruiting
Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage
Led by Southwest Hospital, China · Updated on 2025-05-18
280
Participants Needed
2
Research Sites
187 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, randomized, controlled clinical trial comparing neuroendoscopic hematoma removal to craniotomy in the treatment of large intracerebral hemorrhage.
CONDITIONS
Official Title
Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years, male or female
- Time from symptom onset to first diagnostic CT scan within 24 hours (or if unknown, last known well time within 24 hours)
- Supratentorial intracerebral hemorrhage with hematoma volume ≥50ml or requiring emergency surgery due to space-occupying effect or cerebral hernia signs
- Glasgow Coma Scale score between 5 and 14 before randomization
- National Institutes of Health Stroke Scale score of 6 or higher
- Modified Rankin Scale score of 0-1 before hemorrhage onset
- Randomization within 24 hours after first diagnostic CT
- Informed consent signed by patient or family members
You will not qualify if you...
- Hemorrhage caused by cerebral aneurysm, cerebrovascular malformation, moyamoya disease, brain trauma, brain tumor, massive cerebral infarction hemorrhage transformation, or coagulation dysfunction
- Thalamic hemorrhage or primary ventricular hemorrhage
- Platelet count less than 100×10⁹/L or INR greater than 1.4
- Advanced cerebral hernia or unstable vital signs making surgery intolerable
- Irreversible brain stem impairment or Glasgow Coma Scale score of 4 or less
- History of intracranial bleeding or surgery within past 30 days
- Severe advanced cognitive impairment or inability to complete follow-up
- Serious diseases affecting respiratory, circulatory, digestive, urinary, endocrine, immune, or blood systems
- Pregnant or breastfeeding women, or planning pregnancy within one year
- Participation in other clinical trials (except observational or natural history studies)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Southwest Hospital
Chongqing, Chongqing Municipality, China, 400038
Actively Recruiting
2
Dazhu County People's Hospital
Dazhou, Sichuan, China, 635100
Actively Recruiting
Research Team
R
Rong Hu, MD
CONTACT
H
Hua Feng, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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