Actively Recruiting
The Efficacy and Safety of Non-vItamiN K antaGonist oraL Anticoagulants for intermEdiate Stroke Risk in Patients With Atrial Fibrillation (SINGLE-AF)
Led by Yonsei University · Updated on 2025-02-10
1800
Participants Needed
1
Research Sites
426 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate the efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOAC) in atrial fibrillation patients with intermediate stroke risk (CHA2DS2-VASc score 1 for male, 2 for female). A. Major safety results include major bleeding and clinically relevant non-major bleeding. B. Major efficacy results include strokes, systemic embolism and cardiovascular mortality. C. Other results include myocardial infarction, pulmonary embolism, transient ischemic attack, hospitalization, drug compliance, quality of life questionnaire (AFEQT), cognitive function (KDSQ), aging questionnaire(K-Frail) and hand grip strength.
CONDITIONS
Official Title
The Efficacy and Safety of Non-vItamiN K antaGonist oraL Anticoagulants for intermEdiate Stroke Risk in Patients With Atrial Fibrillation (SINGLE-AF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 19 to 80 years old
- CHA2DS2-VASc score of 1 for males or 2 for females among patients with nonvalvular atrial fibrillation
- Patients willing to register for this study
- Patients who can be followed for progress after treatment
You will not qualify if you...
- Severe liver or kidney dysfunction
- Thyroid dysfunction
- Pregnant or breastfeeding women
- Malignant tumors not completely cured
- Severe structural heart disease
- Predicted survival less than 12 months
- Patients who do not understand or disagree with the study content
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Severance Cardiovascular Hospital Yonsei University
Seoul, South Korea
Actively Recruiting
Research Team
B
Boyoung Joung
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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