Actively Recruiting
Efficacy, Safety, Pharmacokinetics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis
Led by Beijing InnoCare Pharma Tech Co., Ltd. · Updated on 2026-02-09
383
Participants Needed
46
Research Sites
97 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study to evaluate the efficacy, safety, PK characteristics of ICP-488 in Chinese adults with moderate to severe plaque psoriasis.
CONDITIONS
Official Title
Efficacy, Safety, Pharmacokinetics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily agree to participate and sign informed consent
- Male or female aged 18 to 75 years
- History of plaque psoriasis for at least 6 months
- Currently receiving systemic therapy and/or phototherapy
- Psoriasis Area and Severity Index (PASI) score of 12 or higher
- Psoriasis affecting 10% or more of body surface area
- Static Physician Global Assessment (sPGA) score of 3 or higher
You will not qualify if you...
- Diagnosis of non-plaque psoriasis
- Other skin diseases that interfere with study assessments
- Presence of infection or immune-related diseases
- History of tuberculosis or at risk for tuberculosis
- Recent related treatment within protocol-defined time windows
- Use of strong CYP1A2/CYP3A4 inhibitors or inducers within 28 days or less than 5 half-lives
- Clinically significant lab abnormalities or test results posing risk
- Pregnant, lactating, or planning pregnancy during the study
- History of severe drug allergies
- Any other condition deemed unsuitable by the investigator for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 46 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230022
Completed
2
The Second Affiliated Hospital of Wannan Medical College
Wuhu, Anhui, China, 241000
Completed
3
Beijing Chao-Yang Hospital，Capital Medical University
Beijing, Beijing Municipality, China, 100020
Completed
4
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100050
Completed
5
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
Completed
6
Beijing Tongren Hospital,CMU
Beijing, Beijing Municipality, China, 100730
Completed
7
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400016
Completed
8
Chongqing Traditional Chinese Medicine Hospital
Chongqing, Chongqing Municipality, China, 400021
Completed
9
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
Completed
10
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350005
Completed
11
Dermatology Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510091
Completed
12
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510120
Completed
13
Liuzhou People's Hospital
Liuzhou, Guangxi, China, 545006
Completed
14
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China, 550001
Completed
15
Affiliated Hospital of Chengde Medical University
Chengde, Hebei, China, 067000
Completed
16
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050000
Completed
17
The 2nd Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150001
Completed
18
The Second Affiliated Hospital of Henan University of Science and technology
Luoyang, Henan, China, 471000
Completed
19
Nanyang Central Hospital
Nanyang, Henan, China, 473000
Completed
20
Sanmenxia Central Hospital
Sanmenxia, Henan, China, 472000
Completed
21
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 450003
Completed
22
Jingzhou Central Hospital
Jingzhou, Hubei, China, 434020
Completed
23
Wuhan Hospital Of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital)
Wuhan, Hubei, China, 430022
Completed
24
Xiangya Hospital of Central South University
Changsha, Hunan, China, 410008
Completed
25
The Second Xiangya Hospital of Central South
Changsha, Hunan, China, 410011
Completed
26
The First People's Hospital of Changzhou
Changzhou, Jiangsu, China, 213003
Completed
27
The First People's Hospital of Lianyungang
Lianyungang, Jiangsu, China, 222002
Completed
28
Hospital for skin diseases,Institute of dermatology chinese academy of medical sciences，peking union medical college
Nanjing, Jiangsu, China, 210042
Completed
29
First Affiliated Hospital of Gannan Medical University
Ganzhou, Jiangxi, China, 341000
Completed
30
Dermatology Hospital of Jiangxi Province
Nanchang, Jiangxi, China, 330000
Completed
31
The First Hospital of Jilin University
Changchun, Jilin, China, 130021
Completed
32
Northeast International Hospital
Shenyang, Liaoning, China, 110000
Completed
33
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Completed
34
Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200040
Completed
35
Shanghai Skin Disease Hospital skin Disease of tongji University
Shanghai, Shanghai Municipality, China, 200443
Completed
36
Taiyuan Central Hospital
Taiyuan, Shanxi, China, 030009
Completed
37
The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China, 710061
Actively Recruiting
38
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China, 710114
Completed
39
Chengdu Second People's Hospital
Chengdu, Sichuan, China, 610017
Completed
40
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China, 610072
Completed
41
Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
Tianjin, Tianjin Municipality, China, 300120
Completed
42
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China, 650032
Completed
43
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Completed
44
The Fourth Affiliated Hospital, Zhejiang University School of Medicine
Jinhua, Zhejiang, China, 322000
Completed
45
The First Affiliated Hospital Of Ningbo University
Ningbo, Zhejiang, China, 315000
Actively Recruiting
46
The first Affiliated hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Completed
Research Team
A
Alexia Lu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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