Actively Recruiting
The Efficacy and Safety of Precision REpetitive Transcranial Magnetic Stimulation in Alleviating Motor Symptom in Parkinson's Disease
Led by Anhui Medical University · Updated on 2025-06-17
290
Participants Needed
1
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and widely used neuromodulation technology. Small sample studies have shown that rTMS treatment can significantly improve the symptoms of Parkinson's disease(PD) and delay the progression of the disease. In order to further explore the effectiveness of rTMS in the treatment of PD and lay the foundation for its clinical promotion, our research team plans to conduct a randomized double-blind controlled study of rTMS in the treatment of PD in multiple centers across the country.
CONDITIONS
Official Title
The Efficacy and Safety of Precision REpetitive Transcranial Magnetic Stimulation in Alleviating Motor Symptom in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Diagnosed with idiopathic Parkinson's disease according to MDS criteria (2015 Edition)
- No drug adjustments within 4 weeks before treatment and during the entire study
- MDS-UPDRS Part II score of 8 or higher and Hoehn-Yahr stage 1 to 4
- MMSE score of 22 or higher and able to cooperate with behavioral tests and rTMS therapy
You will not qualify if you...
- Previous head MRI or CT showing focal brain injury or severe leukoencephalopathy (Fazekas grade 3 or higher)
- Having secondary parkinsonism syndromes such as vascular or drug-induced parkinsonism
- History of severe head trauma, brain surgery, or deep brain stimulation treatment
- Presence of ferromagnetic implants like cochlear implants or cardiac pacemakers
- History of epilepsy, unexplained loss of consciousness, or current use of anticonvulsant drugs
- Diagnosis of neuropsychiatric disorders other than Parkinson's disease
- History of drug abuse or drug use
- Participation in any clinical trial within the past 6 months
- Pregnant or breastfeeding women or those planning pregnancy within 6 months
- Any other conditions considered unsuitable by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cognitive Neuropsychology Lab Anhui Medical University
Hefei, Anhui, China, 230032
Actively Recruiting
Research Team
P
Panpan Hu, M.D.
CONTACT
K
Kai Wang, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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