Actively Recruiting
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Led by Novartis Pharmaceuticals · Updated on 2026-05-12
360
Participants Needed
102
Research Sites
308 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this Phase 3b study is to assess the efficacy, safety and tolerability of remibrutinib after switching from ocrelizumab and compared to continuous ocrelizumab treatment, in patients living with relapsing multiple sclerosis (plwRMS).
CONDITIONS
Official Title
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 40 to 70 years (inclusive)
- Diagnosis of relapsing multiple sclerosis according to the 2017 McDonald diagnostic criteria
- Currently treated with ocrelizumab at standard dose
- Neurologically stable within 30 days before enrollment
- Suitable for switching to remibrutinib based on physician judgement or patient preference
You will not qualify if you...
- Diagnosis of primary progressive multiple sclerosis according to the revised 2017 McDonald criteria
- History of clinically significant central nervous system diseases or neurological disorders other than MS
- History of confirmed progressive multifocal leukoencephalopathy or related neurological symptoms
- Active clinically significant bacterial, viral, parasitic, or fungal infections
- Active chronic immune system diseases other than MS
- Severe cardiac disease or significant abnormalities on ECG
- Unable to undergo MRI scans
- History of life-threatening infusion or injection reactions to ocrelizumab
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 102 locations
1
Perseverance Research Center
Scottsdale, Arizona, United States, 85253
Actively Recruiting
2
Medstar Washington Hospital Center
Washington D.C., District of Columbia, United States, 20010-2975
Actively Recruiting
3
Neurology of Central FL Res Ctr
Altamonte Springs, Florida, United States, 32714
Actively Recruiting
4
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
5
Neurology Associates PA
Maitland, Florida, United States, 32751
Actively Recruiting
6
Aqualane Clinical Research
Naples, Florida, United States, 34105
Actively Recruiting
7
Advent Health Orlando
Orlando, Florida, United States, 32803
Actively Recruiting
8
Orlando Health Clinical Trials
Orlando, Florida, United States, 32806
Actively Recruiting
9
Tallahassee Neurological Clinic
Tallahassee, Florida, United States, 32308
Actively Recruiting
10
University Of South Florida
Tampa, Florida, United States, 33612
Actively Recruiting
11
Vero Beach Neurology
Vero Beach, Florida, United States, 32960
Actively Recruiting
12
Rush University Medical Center
Chicago, Illinois, United States, 60607
Actively Recruiting
13
University of Kansas Hospital
Kansas City, Kansas, United States, 66160
Actively Recruiting
14
MedStar Montgomery Medical Center
Olney, Maryland, United States, 20832
Actively Recruiting
15
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
16
Lahey Hospital and Medical Center
Burlington, Massachusetts, United States, 01805
Actively Recruiting
17
Neurology Center of New England PC
Foxborough, Massachusetts, United States, 02035
Actively Recruiting
18
Michigan Institute of Neurological
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
19
Memorial HC Ins for Neuroscience
Owosso, Michigan, United States, 48867
Actively Recruiting
20
WA Uni School Of Med
St Louis, Missouri, United States, 63110
Actively Recruiting
21
Cleveland Clinic Foundation
Las Vegas, Nevada, United States, 89106
Actively Recruiting
22
Holy Name Medical Center
Teaneck, New Jersey, United States, 07666
Actively Recruiting
23
University of New Mexico
Albuquerque, New Mexico, United States, 87131-0001
Actively Recruiting
24
SUNY Buffalo The Jacobs Neuro Inst
Buffalo, New York, United States, 14203
Actively Recruiting
25
Velocity Clinical Research
Raleigh, North Carolina, United States, 27607
Actively Recruiting
26
Sanford Health
Fargo, North Dakota, United States, 58122
Actively Recruiting
27
Premier Health
Centerville, Ohio, United States, 45459
Actively Recruiting
28
Univ of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
29
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
30
Ohio Health Research Institute
Columbus, Ohio, United States, 43214
Actively Recruiting
31
Premier Neurology
Greenville, South Carolina, United States, 29605
Actively Recruiting
32
Sibyl Wray MD Neurology PC
Knoxville, Tennessee, United States, 37922
Actively Recruiting
33
Austin Regional Clinic
Austin, Texas, United States, 78731
Actively Recruiting
34
Univ of Texas Southwest Med Center
Dallas, Texas, United States, 75390-9034
Actively Recruiting
35
John Peter Smith Hospital
Fort Worth, Texas, United States, 76104
Actively Recruiting
36
Saturn Research Solutions LLC
Plano, Texas, United States, 75024
Actively Recruiting
37
Center for Neurological Disorders G
Greenfield, Wisconsin, United States, 53228-1321
Actively Recruiting
38
Novartis Investigative Site
Rosario, Santa Fe Province, Argentina, 2000
Actively Recruiting
39
Novartis Investigative Site
Rosario, Santa Fe Province, Argentina, S2000BZL
Actively Recruiting
40
Novartis Investigative Site
Buenos Aires, Argentina, C1012AAR
Actively Recruiting
41
Novartis Investigative Site
Buenos Aires, Argentina, C1055AAF
Actively Recruiting
42
Novartis Investigative Site
Melbourne, Victoria, Australia, 3004
Actively Recruiting
43
Novartis Investigative Site
Parkville, Victoria, Australia, 3050
Actively Recruiting
44
Novartis Investigative Site
Liverpool, Australia, 2170
Actively Recruiting
45
Novartis Investigative Site
St Leonards, Australia, 2065
Actively Recruiting
46
Novartis Investigative Site
Bruges, Belgium, 8000
Actively Recruiting
47
Novartis Investigative Site
Overpelt, Belgium, 3900
Actively Recruiting
48
Novartis Investigative Site
São Paulo, São Paulo, Brazil, 04076-004
Actively Recruiting
49
Novartis Investigative Site
Vancouver, British Columbia, Canada, V6T 2A1
Actively Recruiting
50
Novartis Investigative Site
Lévis, Quebec, Canada, G6W 0M5
Actively Recruiting
51
Novartis Investigative Site
Montreal, Quebec, Canada, H4A 3T2
Actively Recruiting
52
Novartis Investigative Site
Aarhus N, Denmark, 8200
Actively Recruiting
53
Novartis Investigative Site
Glostrup Municipality, Denmark, 2600
Actively Recruiting
54
Novartis Investigative Site
Bordeaux, France, 33076
Actively Recruiting
55
Novartis Investigative Site
Clermont-Ferrand, France, 63003
Actively Recruiting
56
Novartis Investigative Site
Lille, France, 59000
Actively Recruiting
57
Novartis Investigative Site
Marseille, France, 13885
Actively Recruiting
58
Novartis Investigative Site
Nice, France, 06000
Actively Recruiting
59
Novartis Investigative Site
Nîmes, France, 30029
Actively Recruiting
60
Novartis Investigative Site
Paris, France, 75940
Actively Recruiting
61
Novartis Investigative Site
Poitiers, France, 86021
Actively Recruiting
62
Novartis Investigative Site
Strasbourg, France, 67000
Actively Recruiting
63
Novartis Investigative Site
Toulouse, France, 31059
Actively Recruiting
64
Novartis Investigative Site
Tours, France, 37044
Actively Recruiting
65
Novartis Investigative Site
Bochum, Germany, 44791
Actively Recruiting
66
Novartis Investigative Site
Chaïdári, Greece, 124 62
Actively Recruiting
67
Novartis Investigative Site
Larissa, Greece, 411 10
Actively Recruiting
68
Novartis Investigative Site
Thessaloniki, Greece, 53246
Actively Recruiting
69
Novartis Investigative Site
Bergamo, BG, Italy, 24127
Actively Recruiting
70
Novartis Investigative Site
Foggia, FG, Italy, 71122
Actively Recruiting
71
Novartis Investigative Site
Genova, GE, Italy, 16132
Actively Recruiting
72
Novartis Investigative Site
Milan, MI, Italy, 20132
Actively Recruiting
73
Novartis Investigative Site
Pavia, PV, Italy, 27100
Actively Recruiting
74
Novartis Investigative Site
Roma, RM, Italy, 00133
Actively Recruiting
75
Novartis Investigative Site
Roma, RM, Italy, 00168
Actively Recruiting
76
Novartis Investigative Site
Mexico City, Mexico City, Mexico, 06700
Actively Recruiting
77
Novartis Investigative Site
Mexico City, Mexico, 14050
Actively Recruiting
78
Novartis Investigative Site
Braga, Portugal, 4710243
Actively Recruiting
79
Novartis Investigative Site
Coimbra, Portugal, 3004-561
Actively Recruiting
80
Novartis Investigative Site
Lisbon, Portugal, 1169-050
Actively Recruiting
81
Novartis Investigative Site
Bratislava, Slovakia, 826 06
Actively Recruiting
82
Novartis Investigative Site
Trnava, Slovakia, 917 02
Actively Recruiting
83
Novartis Investigative Site
Cape Town, Western Cape, South Africa, 7405
Actively Recruiting
84
Novartis Investigative Site
Pretoria, South Africa, 0041
Actively Recruiting
85
Novartis Investigative Site
Majadahonda, Madrid, Spain, 28222
Actively Recruiting
86
Novartis Investigative Site
El Palmar, Murcia, Spain, 30120
Actively Recruiting
87
Novartis Investigative Site
Valencia, Valencia, Spain, 46017
Actively Recruiting
88
Novartis Investigative Site
Barcelona, Spain, 08035
Actively Recruiting
89
Novartis Investigative Site
Córdoba, Spain, 14004
Actively Recruiting
90
Novartis Investigative Site
Madrid, Spain, 28009
Actively Recruiting
91
Novartis Investigative Site
Madrid, Spain, 28034
Actively Recruiting
92
Novartis Investigative Site
Madrid, Spain, 28040
Actively Recruiting
93
Novartis Investigative Site
Málaga, Spain, 29010
Actively Recruiting
94
Novartis Investigative Site
Seville, Spain, 41009
Actively Recruiting
95
Novartis Investigative Site
Valencia, Spain, 46026
Actively Recruiting
96
Novartis Investigative Site
Bern, Switzerland, 3010
Actively Recruiting
97
Novartis Investigative Site
Lausanne, Switzerland, 1011
Actively Recruiting
98
Novartis Investigative Site
Zurich, Switzerland, 8091
Actively Recruiting
99
Novartis Investigative Site
Sheffield, South Yorkshire, United Kingdom, S10 2JF
Actively Recruiting
100
Novartis Investigative Site
Leeds, United Kingdom, LS1 3EX
Actively Recruiting
101
Novartis Investigative Site
London, United Kingdom, W6 8RF
Actively Recruiting
102
Novartis Investigative Site
Swansea, United Kingdom, SA6 6NL
Actively Recruiting
Research Team
N
Novartis Pharmaceuticals
CONTACT
N
Novartis Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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