Actively Recruiting
Efficacy and Safety of rTMS Combined With HA in the Treatment of Cognitive Decline in Aged Related Hearing Loss
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2026-02-05
189
Participants Needed
1
Research Sites
174 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a real-world interventional trial enrolling 189 participants: older adults with age-related hearing loss not using hearing aids (ARHL-nonHA), those using hearing aids (ARHL-HA), and those with normal hearing (HC). All groups will undergo hearing, cognitive (MMSE, MoCA, SCWT, DST, TMT), depression (GDS-15, HAMD-24), sleep (PSQI), and brain imaging (EEG, sMRI, rs-fMRI, task-fMRI) assessments. The ARHL-nonHA and ARHL-HA groups will receive two 14-day courses of high-frequency rTMS (one session daily). One month after treatment, reassessments will be conducted in these two groups. Data will then be analyzed to evaluate the cognitive benefits of rTMS combined with hearing aids and to explore the underlying brain mechanisms.
CONDITIONS
Official Title
Efficacy and Safety of rTMS Combined With HA in the Treatment of Cognitive Decline in Aged Related Hearing Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 50 and 85 years, any gender
- Diagnosed with age-related hearing loss with symmetrical, slow progression and reduced speech recognition (for ARHL groups)
- Moderate to severe hearing loss in the better ear (PTA 35 to 79 dB) (for ARHL groups)
- Wearing hearing aids for over half a year with daily use exceeding 7.2 hours (for ARHL-HA group)
- Chinese nationals able to complete assessments in Chinese
- Right-handed
- At least 6 years of education
- Provided informed consent and plans to stay in the area for at least one year
You will not qualify if you...
- Hearing loss caused by noise, genetics, ototoxic drugs, or other non-age-related reasons
- History of central nervous system disorders like stroke, epilepsy, or brain injury
- Diagnosed dementia or other neurodegenerative diseases affecting study compliance
- Major neurological or systemic diseases, hereditary conditions, or serious psychiatric disorders
- Contraindications to MRI
- Contraindications to rTMS
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 5100000
Actively Recruiting
Research Team
Y
Yang Haidi, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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