Actively Recruiting
Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)
Led by Ruijun Ji · Updated on 2025-08-12
300
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
R
Ruijun Ji
Lead Sponsor
X
Xing'an League People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
EXCELLENT was a prospective, multicenter, randomized, double-blind, placebo-controlled clinical study in which participants were randomized participants were randomized (1:1) to receive either IV thrombolysis + edaravone or IV thrombolysis + matched placebo (same volume of tablets without drug components), and the primary outcome was the proportion of patients with transformed bleeding on MRI at 72 hours following revascularization therapy.
CONDITIONS
Official Title
Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-80 years
- Acute ischemic stroke confirmed by cranial CT according to WHO definition
- Stroke onset within 4.5 hours
- NIHSS score between 6 and 24
- Eligible for intravenous thrombolysis per international guidelines
- Patient or family provides consent
You will not qualify if you...
- Pregnant women, women in labor, or patients in the puerperium
- Presence of other serious diseases affecting outcome determination
- Presence of other serious diseases affecting prognostic regression
- Presence of other serious diseases with life expectancy less than 1 year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital of Capital Medical University
Beijing, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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