Actively Recruiting
Efficacy and Safety of tACS vs tDCS in Schizophrenia
Led by All India Institute of Medical Sciences, Bhubaneswar · Updated on 2024-07-10
90
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
Sponsors
A
All India Institute of Medical Sciences, Bhubaneswar
Lead Sponsor
I
Indian Council of Medical Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial aims to compare the efficacy and safety of transcranial Alternating current stimulation (tACS) vs. transcranial Direct current stimulation (tDCS) vs. sham stimulation in chronic schizophrenia. The main question it aims to answer is: • In comparison to tDCS, can tACS improve the clinical outcome of patients with chronic schizophrenia? Participants will be randomised into 3 groups receiving either tDCS, tACS or sham stimulation and changes in psychopathology and neuro-cognition with the interventions will be compared within and between the groups. The primary outcome measure is the Positive and Negative Syndrome Scale (PANSS), while secondary outcome measures are the Auditory Hallucination Rating Scale (AHRS), Brief Cognitive Assessment Tool for Schizophrenia (B-CATS), and Global Assessment of Functioning (GAF).
CONDITIONS
Official Title
Efficacy and Safety of tACS vs tDCS in Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of schizophrenia for more than 2 years according to ICD-10 DCR
- Moderate to severe symptoms with PANSS score over 75 and/or CGI-SCH score over 4
- Stable dose of antipsychotic medications with no changes for at least 1 month before enrollment
- Age between 18 and 60 years
- Right-handed
- Provided written informed consent
You will not qualify if you...
- Presence of psychiatric emergencies such as suicidal risk, catatonia, or prolonged nutritional deprivation
- Aggression or excitement at the time of enrollment
- Contraindications to tDCS including metal in the head, implanted brain medical devices, or local scalp/head lesions or injuries
- Co-existing neurological diseases
- Left-handedness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
All India Institute of Medical Scinces - Bhubaneswar
Bhubaneswar, Odisha, India, 751019
Actively Recruiting
Research Team
B
Biswa R Mishra
CONTACT
D
Debadatta Mohapatra
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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