Actively Recruiting
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
Led by First Affiliated Hospital of Zhejiang University · Updated on 2025-02-11
82
Participants Needed
1
Research Sites
36 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. To clarify the efficacy and safety of task-based repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with stable bipolar disorder. 2. To analyze the therapeutic mechanism of transcranial magnetic stimulation based on magnetic resonance imaging and explore the abnormal regulation mechanism of cognitive neural circuits.
CONDITIONS
Official Title
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 14 to 45 years and right-handed
- Diagnosed with bipolar disorder in stable remission according to DSM-5 criteria
- On stable medication treatment
- Clinical remission for over 3 months with Young Mania Rating Scale (YMRS) 64 6 and Hamilton Depression Rating Scale 17 (HDRS 17) 64 7
- Cognitive impairment with Cognitive Deficit Questionnaire (PDQ) score 5 17
- Understands the rTMS treatment, willing to cooperate, and has signed informed consent
You will not qualify if you...
- History of severe physical illness or diseases affecting the central nervous system (e.g., tumors, syphilis)
- Neurological diseases or risk of epileptic seizures, including previous brain diseases, head trauma, alcoholism, abnormal EEG, abnormal brain structure on MRI, or family history of epilepsy
- Contraindications to MRI or rTMS, such as metal or electronic implants in the body (metal in brain, cochlear implants, pacemakers, stents)
- High risk of suicide or past serious self-harm needing emergency intervention
- Pregnant, breastfeeding, or planning pregnancy during the study
- Color blindness or hearing impairment
- History of substance or alcohol abuse
- Other conditions deemed unsuitable by the researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
S
Shaohua Hu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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