Actively Recruiting
The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBP
Led by Peking University People's Hospital · Updated on 2025-06-03
30
Participants Needed
15
Research Sites
178 weeks
Total Duration
On this page
Sponsors
P
Peking University People's Hospital
Lead Sponsor
U
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective multi-center study to investigate efficacy and safety of the third generation tyrosine kinase inhibitors (TKIs) combined with azacitidine and B-cell lymphoma-2 (Bcl-2) inhibitor in patients with myeloid blast phase chronic myeloid leukemia (CML-MBP).
CONDITIONS
Official Title
The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Philadelphia chromosome (Ph)-positive or BCR::ABL-positive chronic myeloid leukemia
- Serum creatinine level less than or equal to 1.5 times the upper limit of normal (ULN) or creatinine clearance at least 50 mL/min if serum creatinine is above 1.5 times ULN
- Serum total bilirubin less than or equal to 1.5 times ULN
- Aspartate aminotransferase and alanine aminotransferase levels less than or equal to 2.5 times ULN
- Amylase level less than or equal to 1.5 times ULN
- Lipase level less than or equal to 1.5 times ULN
- Ejection fraction greater than 50%
- Corrected QT interval on electrocardiogram less than or equal to 450 ms in men or 470 ms in women
You will not qualify if you...
- Having other diseases requiring treatments that might interact with third-generation TKIs
- Diagnosis of other primary cancers
- History of allogeneic hematopoietic stem cell transplant
- Having only extramedullary disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Peking university people's hospital
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
2
Beijing Lu Daopei Hospital
Beijing, China
Actively Recruiting
3
Chuiyangliu hospital affiliated to tsinghua university
Beijing, China
Not Yet Recruiting
4
Sichuan Provincial People's Hospital
Chengdu, China
Not Yet Recruiting
5
Nanfang Hospital, Southern Medical University
Guangdong, China
Not Yet Recruiting
6
The First Affiliated Hospital of Kunming Medical University
Kunming, China
Not Yet Recruiting
7
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China
Actively Recruiting
8
The First Affiliated Hospital of Guangxi Medical University
Nanning, China
Actively Recruiting
9
Nanyang Central Hospital
Nanyang, China
Actively Recruiting
10
Ningbo Medical Center Lihuili Hospital
Ningbo, China
Actively Recruiting
11
Qilu Hospital of Shandong University
Qilu, China
Not Yet Recruiting
12
Chinese Academy of Medical Sciences & Peking Union Medical College Hospital
Tianjin, China
Not Yet Recruiting
13
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Henan Cancer Hospital
Wuhan, China
Not Yet Recruiting
14
Xi'an International Medical Center Hospital
Xi'an, China
Actively Recruiting
15
The First Affiliated Hospital, Zhejiang University School of Medicine
Zhejiang, China
Actively Recruiting
Research Team
Q
Qian Jiang, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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