Actively Recruiting
Efficacy and Safety of Tocilizumab in the Treatment of Generalized Myasthenia Gravis
Led by Tang-Du Hospital · Updated on 2025-05-01
64
Participants Needed
6
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Randomized, double-blind, placebo-controlled, parallel-group study with optional open-label extension.
CONDITIONS
Official Title
Efficacy and Safety of Tocilizumab in the Treatment of Generalized Myasthenia Gravis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of myasthenia gravis with anti-AChR antibody
- MGFA Clinical Classification Class II, III, or IV
- MG-ADL score of 5 or greater at screening and randomization, with over 50% due to non-ocular symptoms
- QMG score of 11 or greater
- Use of cholinesterase inhibitor with no dose increase in 4 weeks before randomization
- Use of corticosteroids with no dose increase in 4 weeks before randomization
- Use of non-steroidal immunosuppressant for at least 6 months with no dose increase in 4 months before randomization
You will not qualify if you...
- Active or severe infections in the 4 weeks before randomization
- History of high-risk or acquired tuberculosis infection, or chronic hepatitis
- Human immunodeficiency virus (HIV) infection
- Thymomas with recent or planned thymectomy within 6 months before randomization, or requiring chemotherapy or radiotherapy
- Rituximab treatment in the past 6 months before randomization
- Tocilizumab or eculizumab treatment within 3 months before randomization
- Intravenous immunoglobulin (IVIG) or plasma exchange within 4 weeks before randomization
- Unresected thymoma
- History of other tumor diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100050
Not Yet Recruiting
2
Xiangya Hospital Central South University
Changsha, Hunan, China, 410008
Not Yet Recruiting
3
Tangdu Hospital, The Fourth Military Medical University
Xi'an, Shaanxi, China, 710038
Actively Recruiting
4
Huashan Hospital
Shanghai, Shanghai Municipality, China, 200040
Not Yet Recruiting
5
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610041
Not Yet Recruiting
6
Tianjin medical university general hospital
Tianjin, Tianjin Municipality, China, 300052
Not Yet Recruiting
Research Team
T
Ting Chang, MD,PHD
CONTACT
Z
Zhe Ruan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here