Actively Recruiting
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
Led by Sanofi · Updated on 2026-05-08
942
Participants Needed
194
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype. Participation to the study consists of 3 periods: * Screening period of up to 4 weeks * Randomized intervention period of approximately 48 weeks * Follow-up period: Approximately 8 weeks The study duration will be up to 60 weeks.
CONDITIONS
Official Title
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 40 to 80 years of age
- Physician diagnosed chronic obstructive pulmonary disease (COPD) for at least 1 year
- Post-bronchodilator forced expiratory volume in 1 second (post-BD FEV1) between 20% and 70% of predicted value and FEV1/FVC ratio less than 0.70
- Former or current smokers with at least 10 pack-years
- Chronic Airways Assessment Test (CAAT) score of 10 or higher
- At least 2 moderate or 1 severe COPD exacerbations in the prior year
- On triple COPD therapy (ICS+LABA+LAMA) for at least 12 consecutive weeks
- Blood eosinophil count (EOS) of 150 cells/µL or higher
- Body Mass Index between 18.0 and 40.0 kg/m2
You will not qualify if you...
- Asthma, including pediatric asthma, or asthma-COPD overlap syndrome (ACOS)
- Significant pulmonary disease other than COPD
- Long-term oxygen therapy greater than 4.0 L/min or needing more than 2.0 L/min to keep oxygen saturation above 88% at rest
- Unstable health conditions that could affect safety or study results
- Active or incompletely treated tuberculosis
- Current or past cancers
- Use of long-term macrolides or phosphodiesterase Type 3 (PDE-3) or PDE-4 inhibitors unless stable for more than 6 months
- Use of any biologic therapy or systemic immunosuppressants within 4 months or 5 half-lives before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 194 locations
1
Tucson Clinical Research Institute- Site Number : 8400006
Tucson, Arizona, United States, 85712
Actively Recruiting
2
Inglewood Clinical- Site Number : 8400074
Inglewood, California, United States, 90301
Actively Recruiting
3
Ark Clinical Research- Site Number : 8400113
Long Beach, California, United States, 90815
Actively Recruiting
4
Alliance Clinical - West Hills- Site Number : 8400067
Los Angeles, California, United States, 91307
Actively Recruiting
5
California Medical Research Associates - Northridge- Site Number : 8400089
Northridge, California, United States, 91324
Actively Recruiting
6
Alpine Clinical Research Center - Boulder - 47th Street- Site Number : 8400005
Boulder, Colorado, United States, 80301
Actively Recruiting
7
Critical Care Pulmonary & Sleep Associates- Site Number : 8400081
Lakewood, Colorado, United States, 80228
Actively Recruiting
8
Finlay Medical Research - Greenacres- Site Number : 8400107
Greenacres City, Florida, United States, 33467
Actively Recruiting
9
Direct Helpers Research Center- Site Number : 8400057
Hialeah, Florida, United States, 33012
Actively Recruiting
10
Pulmonary Specialists of the Palm Beaches- Site Number : 8400017
Loxahatchee Groves, Florida, United States, 33470
Actively Recruiting
11
DL Research Solutions- Site Number : 8400140
Miami, Florida, United States, 33155
Actively Recruiting
12
Phoenix Medical Research - Miami - 24th Street- Site Number : 8400027
Miami, Florida, United States, 33165
Actively Recruiting
13
Professional Research Center- Site Number : 8400046
Miami, Florida, United States, 33172
Actively Recruiting
14
Research Institute of South Florida- Site Number : 8400028
Miami, Florida, United States, 33173
Actively Recruiting
15
Innovations Biotech- Site Number : 8400019
Miami, Florida, United States, 33186
Actively Recruiting
16
Florida Institute for Clinical Research- Site Number : 8400001
Orlando, Florida, United States, 32825
Actively Recruiting
17
Avanza Medical Research Center- Site Number : 8400015
Pensacola, Florida, United States, 32503
Actively Recruiting
18
Hull and Hull Medical Specialists- Site Number : 8400002
Plantation, Florida, United States, 33324
Actively Recruiting
19
Windom Allergy, Asthma and Sinus Specialists- Site Number : 8400041
Sarasota, Florida, United States, 34239
Actively Recruiting
20
Appalachian Clinical Research- Site Number : 8400060
Adairsville, Georgia, United States, 30103
Actively Recruiting
21
Christie Clinic in Champaign on University- Site Number : 8400023
Champaign, Illinois, United States, 61820
Actively Recruiting
22
Sneeze Wheeze & Itch Associates- Site Number : 8400020
Normal, Illinois, United States, 61761
Actively Recruiting
23
Peoria Pulmonary Associates Ltd- Site Number : 8400095
Peoria, Illinois, United States, 61603
Actively Recruiting
24
Asha Clinical Research - Munster- Site Number : 8400115
Hammond, Indiana, United States, 46324
Actively Recruiting
25
Care Access - Shreveport - Youree Drive- Site Number : 8400007
Shreveport, Louisiana, United States, 71105
Actively Recruiting
26
Lucida Clinical Trials- Site Number : 8400101
New Bedford, Massachusetts, United States, 02740
Actively Recruiting
27
Vitalis Clinical Research Center- Site Number : 8400040
Allen Park, Michigan, United States, 48101
Actively Recruiting
28
Bolt Clinical Research- Site Number : 8400086
Brighton, Michigan, United States, 48116
Actively Recruiting
29
Hannibal Regional Healthcare System- Site Number : 8400035
Hannibal, Missouri, United States, 63401
Actively Recruiting
30
Excel Clinical Research - Las Vegas- Site Number : 8400070
Las Vegas, Nevada, United States, 89109
Actively Recruiting
31
AB Clinical Trials- Site Number : 8400075
Las Vegas, Nevada, United States, 89119
Completed
32
Bioluminux Clinical Research - Hamilton, New Jersey- Site Number : 8400037
Hamilton, New Jersey, United States, 08690
Actively Recruiting
33
Mid Hudson Medical Research - New Windsor- Site Number : 8400004
New Windsor, New York, United States, 12553
Actively Recruiting
34
East Carolina University- Site Number : 8400102
Greenville, North Carolina, United States, 27858
Actively Recruiting
35
Piedmont Healthcare - Family Medicine- Site Number : 8400022
Statesville, North Carolina, United States, 28625
Actively Recruiting
36
All-Trials Clinical Research- Site Number : 8400008
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
37
Asthma & Allergy Center - Toledo- Site Number : 8400110
Toledo, Ohio, United States, 43617
Actively Recruiting
38
Layrek Clinical Research- Site Number : 8400066
Tulsa, Oklahoma, United States, 74133
Actively Recruiting
39
The Oregon Clinic, PC- Site Number : 8400065
Portland, Oregon, United States, 97232
Actively Recruiting
40
MedTrial- Site Number : 8400010
Columbia, South Carolina, United States, 29204
Actively Recruiting
41
Chattanooga Research and Medicine- Site Number : 8400026
Chattanooga, Tennessee, United States, 37404
Actively Recruiting
42
IntraCare- Site Number : 8400034
Dallas, Texas, United States, 75254
Actively Recruiting
43
Premier Pulmonary Critical Care and Sleep- Site Number : 8400111
Denison, Texas, United States, 75020
Actively Recruiting
44
El Paso Pulmonary Association- Site Number : 8400033
El Paso, Texas, United States, 79902
Actively Recruiting
45
Axsendo Clinical Research - Houston- Site Number : 8400054
Houston, Texas, United States, 77058
Actively Recruiting
46
SE Houston- Site Number : 8400120
Houston, Texas, United States, 77061
Actively Recruiting
47
Synergy Group US - Missouri City- Site Number : 8400119
Missouri City, Texas, United States, 77459
Actively Recruiting
48
Synergy Group US - Missouri City- Site Number : 8400133
Missouri City, Texas, United States, 77459
Actively Recruiting
49
Elligo Health Care, Hillcroft Medical Clinic Association- Site Number : 8400053
Sugar Land, Texas, United States, 77478
Actively Recruiting
50
Medrasa Clinical Research - Wylie- Site Number : 8400124
Wylie, Texas, United States, 75098
Actively Recruiting
51
Dominion Medical Associates - Richmond - East Leigh Street- Site Number : 8400154
Richmond, Virginia, United States, 23219
Active, Not Recruiting
52
Rheumatology & Pulmonary Clinic- Site Number : 8400012
Beckley, West Virginia, United States, 25801
Actively Recruiting
53
Investigational Site Number : 0320011
Berazategui, Buenos Aires, Argentina, 1886
Actively Recruiting
54
Investigational Site Number : 0320004
Buenos Aires, Argentina, 1006
Actively Recruiting
55
Investigational Site Number : 0320002
Buenos Aires, Argentina, 1023
Actively Recruiting
56
Investigational Site Number : 0320005
Buenos Aires, Argentina, 1121
Actively Recruiting
57
Investigational Site Number : 0320006
Buenos Aires, Argentina, 1280
Actively Recruiting
58
Investigational Site Number : 0320001
Buenos Aires, Argentina, 1414
Actively Recruiting
59
Investigational Site Number : 0320012
Buenos Aires, Argentina, 1638
Actively Recruiting
60
Investigational Site Number : 0320003
Buenos Aires, Argentina, 1650
Actively Recruiting
61
Investigational Site Number : 0320009
Córdoba, Argentina, 5003
Actively Recruiting
62
Investigational Site Number : 0320007
Mendoza, Argentina, 5500
Actively Recruiting
63
Investigational Site Number : 0320008
Mendoza, Argentina, 5500
Actively Recruiting
64
Investigational Site Number : 0320010
Santa Fe, Argentina, 3000
Actively Recruiting
65
Investigational Site Number : 0360006
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
66
Investigational Site Number : 0360004
Townsville, Queensland, Australia, 4814
Actively Recruiting
67
Investigational Site Number : 0360002
Traralgon, Victoria, Australia, 3844
Actively Recruiting
68
Investigational Site Number : 0360001
Osborne Park, Western Australia, Australia, 6017
Actively Recruiting
69
Investigational Site Number : 5540004
Dunedin, Australia, 9016
Actively Recruiting
70
Universidade Federal de Goias- Site Number : 0760002
Goiânia, Goiás, Brazil, 74605-020
Actively Recruiting
71
Santa Casa de Misericordia de Belo Horizonte- Site Number : 0760004
Belo Horizonte, Minas Gerais, Brazil, 30150-221
Actively Recruiting
72
WM Pesquisas Clínicas em Doenças Respiratórias- Site Number : 0760003
Porto Alegre, Rio Grande do Sul, Brazil, 91010-006
Actively Recruiting
73
Centro Multidisciplinar de Estudos Clínicos- Site Number : 0760001
São Bernardo do Campo, São Paulo, Brazil, 09715-090
Actively Recruiting
74
IBCC - Núcleo de Pesquisa e Ensino- Site Number : 0760005
São Paulo, Brazil, 04014-002
Actively Recruiting
75
Investigational Site Number : 1240051
Kelowna, British Columbia, Canada, V1Y 4N7
Actively Recruiting
76
Investigational Site Number : 1240052
West Vancouver, British Columbia, Canada, V7T 2Z3
Actively Recruiting
77
Investigational Site Number : 1240041
Windsor, Ontario, Canada, N8X 1T3
Actively Recruiting
78
Investigational Site Number : 1240049
Longueuil, Quebec, Canada, J4K 1C8
Actively Recruiting
79
Investigational Site Number : 1240055
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
80
Investigational Site Number : 1240047
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
81
Investigational Site Number : 1240053
Québec, Quebec, Canada, G2J 0C4
Actively Recruiting
82
Investigational Site Number : 1240050
Saint-Charles-Borromée, Quebec, Canada, J6E 2B4
Actively Recruiting
83
Investigational Site Number : 1240054
Saint-Charles-Borromée, Quebec, Canada, J6E 2B4
Actively Recruiting
84
Investigational Site Number : 1240048
Trois-Rivières, Quebec, Canada, G8T 7A1
Actively Recruiting
85
Investigational Site Number : 1240042
Victoriaville, Quebec, Canada, G6P 3Z8
Actively Recruiting
86
Investigational Site Number : 1520006
Temuco, La Araucanía, Chile, 4810345
Actively Recruiting
87
Investigational Site Number : 1520004
Recoleta, Reg Metropolitana de Santiago, Chile, 8420000
Actively Recruiting
88
Investigational Site Number : 1520001
Santiago, Reg Metropolitana de Santiago, Chile, 7500587
Actively Recruiting
89
Investigational Site Number : 1520002
Santiago, Reg Metropolitana de Santiago, Chile, 7750495
Actively Recruiting
90
Investigational Site Number : 1520009
Santiago, Reg Metropolitana de Santiago, Chile, 8380453
Actively Recruiting
91
Investigational Site Number : 1520003
Viña del Mar, Valparaiso, Chile, 2540364
Actively Recruiting
92
Investigational Site Number : 1520007
Chillan, Chile, 3800761
Actively Recruiting
93
Investigational Site Number : 1560003
Baotou, China, 014010
Actively Recruiting
94
Investigational Site Number : 1560022
Beijing, China, 100020
Actively Recruiting
95
Investigational Site Number : 1560001
Beijing, China, 100029
Actively Recruiting
96
Investigational Site Number : 1560023
Beijing, China, 100038
Actively Recruiting
97
Investigational Site Number : 1560005
Beijing, China, 100191
Actively Recruiting
98
Investigational Site Number : 1560090
Changde, China, 415000
Actively Recruiting
99
Investigational Site Number : 1560057
Changsha, China, 410008
Actively Recruiting
100
Investigational Site Number : 1560052
Chengdu, China, 610000
Actively Recruiting
101
Investigational Site Number : 1560032
Chengdu, China, 610081
Actively Recruiting
102
Investigational Site Number : 1560037
Chongqing, China, 400010
Actively Recruiting
103
Investigational Site Number : 1560074
Chongqing, China
Actively Recruiting
104
Investigational Site Number : 1560051
Foshan, China, 528399
Actively Recruiting
105
Investigational Site Number : 1560042
Ganzhou, China, 341000
Actively Recruiting
106
Investigational Site Number : 1560015
Guangzhou, China, 510180
Actively Recruiting
107
Investigational Site Number : 1560034
Guangzhou, China, 511400
Actively Recruiting
108
Investigational Site Number : 1560038
Guiyang, China, 550004
Actively Recruiting
109
Investigational Site Number : 1560016
Haikou, China, 570216
Actively Recruiting
110
Investigational Site Number : 1560009
Hangzhou, China, 310009
Actively Recruiting
111
Investigational Site Number : 1560066
Hangzhou, China, 310009
Actively Recruiting
112
Investigational Site Number : 1560054
Hebei, China, 050051
Actively Recruiting
113
Investigational Site Number : 1560059
Hefei, China, 230011
Actively Recruiting
114
Investigational Site Number : 1560007
Hohhot, China, 010070
Actively Recruiting
115
Investigational Site Number : 1560050
Honghehanizu, China, 654400
Actively Recruiting
116
Investigational Site Number : 1560046
Huaian City, China
Actively Recruiting
117
Investigational Site Number : 1560004
Huizhou, China, 516002
Actively Recruiting
118
Investigational Site Number : 1560021
Huzhou, China, 313000
Actively Recruiting
119
Investigational Site Number : 1560065
Jiangyin, China, 214400
Actively Recruiting
120
Investigational Site Number : 1560081
Jiaxing, China, 314001
Actively Recruiting
121
Investigational Site Number : 1560055
Jinan, China, 250001
Actively Recruiting
122
Investigational Site Number : 1560028
Jinan, China, 250013
Actively Recruiting
123
Investigational Site Number : 1560013
Jinan, China, 250014
Actively Recruiting
124
Investigational Site Number : 1560079
Jingzhou, China, 434020
Actively Recruiting
125
Investigational Site Number : 1560040
Jining, China, 272029
Actively Recruiting
126
Investigational Site Number : 1560061
Kunming, China, 650011
Actively Recruiting
127
Investigational Site Number : 1560077
Luoyang, China, 471002
Actively Recruiting
128
Investigational Site Number : 1560063
Meihekou, China, 135022
Actively Recruiting
129
Investigational Site Number : 1560014
Nanchang, China, 330006
Actively Recruiting
130
Investigational Site Number : 1560087
Nanchang, China, 330008
Actively Recruiting
131
Investigational Site Number : 1560047
Nanjing, China, 210006
Actively Recruiting
132
Investigational Site Number : 1560082
Nanjing, China, 211100
Actively Recruiting
133
Investigational Site Number : 1560018
Nanyang, China, 473014
Actively Recruiting
134
Investigational Site Number : 1560073
Panjin, China, 422000
Actively Recruiting
135
Investigational Site Number : 1560043
Qingyuan, China, 511518
Actively Recruiting
136
Investigational Site Number : 1560025
Qinhuangdao, China, 066000
Actively Recruiting
137
Investigational Site Number : 1560031
Qiqihar, China, 161000
Actively Recruiting
138
Investigational Site Number : 1560045
Quzhou, China, 324000
Actively Recruiting
139
Investigational Site Number : 1560008
Shanghai, China, 200025
Actively Recruiting
140
Investigational Site Number : 1560017
Shanghai, China, 201200
Actively Recruiting
141
Investigational Site Number : 1560072
Shaoyang, China, 422000
Actively Recruiting
142
Investigational Site Number : 1560035
Shenyang, China, 110000
Actively Recruiting
143
Investigational Site Number : 1560053
Shijiazhuang, China, 050031
Actively Recruiting
144
Investigational Site Number : 1560002
Suzhou, China, 215006
Actively Recruiting
145
Investigational Site Number : 1560024
Taiyuan, China, 030032
Actively Recruiting
146
Investigational Site Number : 1560075
Ürümqi, China, 830001
Actively Recruiting
147
Investigational Site Number : 1560033
Weifang, China, 261041
Actively Recruiting
148
Investigational Site Number : 1560036
Wenzhou, China, 325027
Actively Recruiting
149
Investigational Site Number : 1560019
Wuhan, China, 430014
Actively Recruiting
150
Investigational Site Number : 1560071
Wuhan, China, 430022
Actively Recruiting
151
Investigational Site Number : 1560070
Xi'an, China, 710004
Actively Recruiting
152
Investigational Site Number : 1560020
Xi'an, China, 710126
Actively Recruiting
153
Investigational Site Number : 1560083
Xiangyang, China, 441021
Actively Recruiting
154
Investigational Site Number : 1560006
Xinxiang, China, 453000
Actively Recruiting
155
Investigational Site Number : 1560058
Xuzhou, China, 221018
Actively Recruiting
156
Investigational Site Number : 1560089
Yinchuan, China, 750004
Actively Recruiting
157
Investigational Site Number : 1560076
Yiyang, China, 413000
Actively Recruiting
158
Investigational Site Number : 1560044
Zhangzhou, China, 363000
Actively Recruiting
159
Investigational Site Number : 1560084
Zigong, China, 643000
Actively Recruiting
160
Investigational Site Number : 1560039
Zunyi, China, 563002
Actively Recruiting
161
Investigational Site Number : 4580005
Miri, Malaysia, 98000
Actively Recruiting
162
Investigational Site Number : 4580007
Sibu, Malaysia, 96000
Actively Recruiting
163
Investigational Site Number : 5540003
Christchurch, Canterbury, New Zealand, 8011
Actively Recruiting
164
Investigational Site Number : 5540002
Ebdentown, Wellington Region, New Zealand, 5018
Actively Recruiting
165
Investigational Site Number : 5540001
Auckland, New Zealand, 0622
Actively Recruiting
166
Investigational Site Number : 7020001
Singapore, Singapore, 529889
Actively Recruiting
167
Investigational Site Number : 7100001
Cape Town, Alberta, South Africa, 7530
Actively Recruiting
168
Investigational Site Number : 7100003
Cape Town, South Africa, 7764
Actively Recruiting
169
Investigational Site Number : 7100013
Krugersdorp, South Africa, 1739
Actively Recruiting
170
Investigational Site Number : 7100012
Pretoria, South Africa, 0084
Actively Recruiting
171
Investigational Site Number : 4100007
Anyang-si, Gyeonggi-do, South Korea, 14068
Actively Recruiting
172
Investigational Site Number : 4100005
Daegu, Gyeongsangbuk-do, South Korea, 42415
Actively Recruiting
173
Investigational Site Number : 4100003
Jeonju, Jeollabuk-do, South Korea, 54907
Actively Recruiting
174
Investigational Site Number : 4100004
Seoul, Seoul-teukbyeolsi, South Korea, 05030
Actively Recruiting
175
Investigational Site Number : 4100002
Seoul, Seoul-teukbyeolsi, South Korea, 05355
Actively Recruiting
176
Investigational Site Number : 4100001
Seoul, Seoul-teukbyeolsi, South Korea, 06591
Actively Recruiting
177
Investigational Site Number : 4100006
Seoul, Seoul-teukbyeolsi, South Korea, 07061
Actively Recruiting
178
Investigational Site Number : 1580007
Changhua, Taiwan, 500
Actively Recruiting
179
Investigational Site Number : 1580006
Guishan, Taiwan, 333
Actively Recruiting
180
Investigational Site Number : 1580008
Hsinchu, Taiwan, 300
Actively Recruiting
181
Investigational Site Number : 1580001
Kaohsiung City, Taiwan, 807
Actively Recruiting
182
Investigational Site Number : 1580005
Taipei, Taiwan, 100
Actively Recruiting
183
Investigational Site Number : 1580002
Taipei, Taiwan, 110
Actively Recruiting
184
Investigational Site Number : 1580003
Taipei, Taiwan, 112
Actively Recruiting
185
Investigational Site Number : 8260035
Milton Keynes, Buckinghamshire, United Kingdom, MK19 6FG
Actively Recruiting
186
Investigational Site Number : 8260007
London, England, United Kingdom, E11 1NR
Actively Recruiting
187
Investigational Site Number : 8260008
London, Hammersmith and Fulham, United Kingdom, W6 8RF
Actively Recruiting
188
Investigational Site Number : 8260006
Southampton, Hampshire, United Kingdom, SO16 6YD
Actively Recruiting
189
Investigational Site Number : 8260001
London, London, City of, United Kingdom, Se1 7eh
Actively Recruiting
190
Investigational Site Number : 8260016
London, London, City of, United Kingdom, SW1P 2PF
Actively Recruiting
191
Investigational Site Number : 8260030
Salford, Manchester, United Kingdom, M6 8HD
Actively Recruiting
192
Investigational Site Number : 8260013
Chertsey, Surrey, United Kingdom, KT16 0PZ
Actively Recruiting
193
Investigational Site Number : 8260005
Reading, United Kingdom, RG1 5AN
Actively Recruiting
194
Investigational Site Number : 8260017
Rotherham, United Kingdom, S61 1AH
Actively Recruiting
Research Team
T
Trial Transparency email recommended (Toll free for US & Canada)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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