Actively Recruiting
An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
Led by Vertex Pharmaceuticals Incorporated · Updated on 2026-03-23
10
Participants Needed
7
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant.
CONDITIONS
Official Title
An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical history of Type 1 Diabetes with at least 5 years of insulin dependence
- Taking a stable immunosuppression regimen of tacrolimus and mycophenolate mofetil, mycophenolate sodium, or sirolimus for at least 4 weeks
- Consistent use of continuous glucose monitor (CGM) for at least 4 weeks before screening and willingness to use CGM throughout the study
You will not qualify if you...
- Prior islet cell transplant, organ transplant other than kidney transplant, or cell therapy, except a pancreatic graft that failed within the first 4 weeks
- More than one kidney transplant procedure
- Other protocol-defined inclusion/exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Perelman Center for Advanced Medicine - Endocrinology
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
2
Montefiore Clinical and Translational Research Center - Endocrinology
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
3
UW University Hospital - Endocrinology
Madison, Wisconsin, United States, 53792
Actively Recruiting
4
Toronto General Hospital - Endocrinology
Toronto, Canada
Actively Recruiting
5
Vancouver General Hospital - Gordon and Leslie Diamond Health Care Centre
Vancouver, Canada
Actively Recruiting
6
King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology
Riyadh, Saudi Arabia
Actively Recruiting
7
King Faisal Specialist Hospital & Research Centre - Riyadh - Endocrinology
Riyadh, Saudi Arabia
Actively Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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