Actively Recruiting
Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease
Led by Fujian Medical University Union Hospital · Updated on 2026-01-14
66
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is grounded in the regulatory mechanisms of the glymphatic system and applies repetitive transcranial magnetic stimulation (rTMS) to the treatment of Alzheimer's disease (AD). The clinical efficacy and safety of rTMS will be systematically evaluated. Furthermore, transcranial magnetic stimulation-evoked potentials (TMS-EEG) and functional near-infrared spectroscopy (fNIRS) will be employed to investigate, from the perspectives of synaptic plasticity and neurovascular coupling, the mechanisms by which rTMS influences glymphatic function. Collectively, this work aims to provide new insights into both the therapeutic effectiveness and the underlying mechanisms of rTMS in AD.
CONDITIONS
Official Title
Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets the 2018 NIA-AA diagnostic criteria for Alzheimer's disease (AD)
- Meets DSM-5 diagnostic criteria
- Mild to moderate disease severity with a Clinical Dementia Rating (CDR) Global Score of 1 to 2
- Evidence of Alzheimer's disease pathology confirmed by positive amyloid PET, cerebrospinal fluid (CSF) AD biomarkers, or plasma AD biomarkers
- Age between 50 and 90 years
You will not qualify if you...
- Contraindications to repetitive transcranial magnetic stimulation (rTMS) treatment
- Severe complications or immune diseases
- Unable to cooperate with study procedures
- History of epilepsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
rTMS
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
X
Xiaodong Pan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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