Actively Recruiting
Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) for Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder (NMOSD)
Led by Tang-Du Hospital · Updated on 2026-01-29
12
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an open-label, single-arm, single-center prospective pilot study to assess the efficacy and safety of transcranial temperol interference stimulation in patients with neuromyelitis optica spectrum disorder (NMOSD) complicated by neuropathic pain in China.
CONDITIONS
Official Title
Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) for Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder (NMOSD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with NMOSD according to International Panel for Neuromyelitis Optica Diagnosis criteria
- Neuropathic pain with a DN4 score of 4 or higher
- Pain Numerical Rating Scale (NRS) score of 4 or more, lasting over 3 months
- Receiving biological therapy and/or prednisone at a stable dose with no changes in the last 30 days
- No changes in standard analgesic drugs (antiepileptic, antidepressants, opioids) in the last 30 days
- Signed written informed consent by patients or family members
You will not qualify if you...
- Participation in other clinical studies
- Use of investigational pain control drugs within 30 days before enrollment
- Diagnosis of peripheral neuropathy
- Active central nervous system diseases
- Cognitive or mental disorders
- Pregnancy, lactation, or planning pregnancy during study
- Severe heart, liver, kidney, or blood diseases
- Implanted devices such as pacemakers or nerve stimulators
- History of allergy or intolerance to TENS or latex
- Contraindications to MRI
- Head skin lesions
- Other medical conditions or situations that may affect study outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tangdu Hospital
Xi'an, Shaanxi, China, 710038
Actively Recruiting
Research Team
J
Jun GUO, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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