Actively Recruiting
Efficacy of SGLT2 Inhibitors in Adults With Sepsis
Led by Hospital Authority, Hong Kong · Updated on 2025-03-19
60
Participants Needed
3
Research Sites
103 weeks
Total Duration
On this page
Sponsors
H
Hospital Authority, Hong Kong
Lead Sponsor
C
Chinese University of Hong Kong
Collaborating Sponsor
AI-Summary
What this Trial Is About
Goal of this clinical trial is to examine the safety and efficacy of SGLT2 inhibitors on the clinical outcomes in patients with sepsis. Main study outcomes are as follows: (i) Primary objective is to examine the efficacy and safety of SGLT2 inhibitors on clinical outcomes in patients with sepsis. (ii) Secondary objective is to examine the effect of SGLT2 inhibitors on inflammatory markers in patients with sepsis.
CONDITIONS
Official Title
Efficacy of SGLT2 Inhibitors in Adults With Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or above
- New onset of sepsis within 48 hours defined according to the Sepsis-3 criteria (≥2 SOFA)
- Provision of signed and dated informed consent form from participant or surrogate
- Ability to take and adhere to oral and enteral medication regimen
- Willingness to comply
You will not qualify if you...
- Current or recent use of SGLT2 inhibitors within 12 weeks prior to randomization
- Impaired renal function
- Clinically unstable or in refractory hypotension
- History of ketoacidosis
- Gastrointestinal surgery or gastrointestinal absorption/malabsorption disorder
- Pregnancy
- Known allergic or hypersensitivity reactions to any SGLT2 inhibitors
- Treatment with another investigational drug or other interventions within 30 days prior to trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
4/F Main Clinical Block and Trauma Centre, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Hong Kong, Hong Kong, Hong Kong, 0000
Not Yet Recruiting
2
Adult Intensive Care Unit, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong
Hong Kong, Hong Kong, Hong Kong, 0000
Actively Recruiting
3
The University of Hong Kong
Hong Kong, Hong Kong, 00
Actively Recruiting
Research Team
P
Pauline Yeung Ng, MBBS, FHKCP
CONTACT
C
Calvin Tam, BSN, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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