Actively Recruiting
Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost
Led by Prairie Eye Center · Updated on 2025-05-15
70
Participants Needed
1
Research Sites
46 weeks
Total Duration
On this page
Sponsors
P
Prairie Eye Center
Lead Sponsor
S
Sengi
Collaborating Sponsor
AI-Summary
What this Trial Is About
A randomized, multi-site, parallel-group, prospective study of patients who are adults with a diagnosis of mild to moderate open-angle glaucoma (OAG), currently on an on-label use of combination topical medication of Cosopt and Latanoprost for a minimum of 1 month.
CONDITIONS
Official Title
Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older with mild to moderate open-angle glaucoma
- Currently using combination of Cosopt and Latanoprost eye drops for at least 1 month
- Evidence of optic nerve damage based on AAO guidelines such as optic disc or retinal nerve fiber layer abnormalities
- Reliable and reproducible visual field defects consistent with retinal nerve fiber layer damage
- Mean diurnal intraocular pressure between 18 and less than 28 mmHg in at least one eye with less than 5 mmHg difference between eyes
- Central corneal thickness between 450 and 650 micrometers
You will not qualify if you...
- Prior ocular procedures or intraocular surgery within 1 year before baseline
- History of glaucoma surgeries or laser treatment except selective laser trabeculoplasty more than 1 year before baseline
- Known allergy or sensitivity to study medications (Rocklatan, Simbrinza, Cosopt, Latanoprost) or related drugs
- Uncontrolled systemic diseases that may increase risk or limit study adherence
- Significant ocular diseases preventing accurate intraocular pressure measurement
- History of uncontrolled intraocular pressure on Rocklatan + Simbrinza or Cosopt + Latanoprost dual therapy
- Significant ocular surface problems like hyperemia or irritation
- Chronic use of systemic medications that may affect intraocular pressure
- Pregnant, lactating, or planning pregnancy
- Any condition that might interfere with study results as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prairie Eye Center
Springfield, Illinois, United States, 62704
Actively Recruiting
Research Team
J
Jennifer Lyons
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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