Actively Recruiting
The Efficacy of a Smart Phone-based Test on Measuring Pupillary Light Reflex Alterations Following Cannabis Use Healthy in Adults
Led by Sobereye Inc. · Updated on 2025-07-17
20
Participants Needed
1
Research Sites
10 weeks
Total Duration
On this page
Sponsors
S
Sobereye Inc.
Lead Sponsor
K
KGK Science Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this open label study is to evaluate the efficacy of smart phone-based test (SOBEREYE OPTOVERA) on measuring pupillary light reflex (PLR) alterations following cannabis use healthy in adults. The main question it aims to answer is: Can SOBEREYE OPTOVERA detect PLR alterations following cannabis consumption in healthy adults, in comparison to a pupillometer? Participants will be given two 5 mg capsules to be ingested for the 10 mg THC dose or five 5 mg capsules to be ingested for the 25 mg THC. Participants will be asked to complete PLR tests throughout the study day.
CONDITIONS
Official Title
The Efficacy of a Smart Phone-based Test on Measuring Pupillary Light Reflex Alterations Following Cannabis Use Healthy in Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 21 years of age or older
- Females not of child-bearing potential (sterilized or post-menopausal for at least 1 year) or, if of child-bearing potential, must have a negative pregnancy test and agree to use approved birth control during the study
- Self-reported cannabis users familiar with THC effects without severe adverse reactions
- Cannabis use at least 3 times per month but no more than 3 times per week
- Agree to abstain from cannabis for 3 days before the study visit
- Willing to complete all study assessments and arrange safe transportation home
- Provided voluntary, written informed consent to participate
You will not qualify if you...
- Pregnant, breastfeeding, or planning pregnancy during the study
- Allergy, sensitivity, intolerance, or dietary restrictions preventing consumption of study products
- Current or ongoing neurological or eye issues affecting the retina or pupil (including blindness, glaucoma, dry eyes, retinal diseases, pupil abnormalities, cataracts, light sensitivity)
- History of eye or retina surgery except laser corneal surgery
- Current or past psychological disorders such as schizophrenia or psychosis
- Significant gastrointestinal diseases
- Type I or II diabetes with diabetic retinopathy
- Unstable metabolic or chronic diseases
- Unstable hypertension unless on stable medication for at least 3 months
- Significant cardiovascular event in past 6 months unless stable on medication
- Kidney or liver diseases except resolved kidney stones
- Confirmed thyroid condition unless stable on medication for at least 3 months
- Major surgery in past 3 months or planned during study
- Cancer except fully excised basal cell carcinoma or remission over 5 years
- Unstable autoimmune disease
- HIV, Hepatitis B or C infection
- Alcohol or drug abuse in last 12 months
- Impairment from drugs or alcohol during study visit
- Alcohol intake averaging more than 2 standard drinks per day
- Use of medications, supplements, or foods affecting study product safety or efficacy
- Participation in other research within 30 days prior to baseline
- Cognitive impairment or inability to give informed consent
- Any condition or lifestyle factor posing risk or affecting study completion as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
KGK Science Inc.
London, Ontario, Canada
Actively Recruiting
Research Team
E
Erin Lewis, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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