Efficacy of Surgical Glove-Compression Therapy to Prevent Paclitaxel-Induced Peripheral Neuropathy: Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating the effectiveness of surgical glove-compression therapy (SGCT) in preventing sensory peripheral neuropathy caused by paclitaxel chemotherapy. This randomized controlled trial compares the incidence of grade 2 or higher sensory peripheral neuropathy between patients using SGCT and those wearing non-compressive plastic gloves, aiming to find out if SGCT can reduce this side effect. The study also looks at motor neuropathy and other neuropathy-related scores and tests. Participants are randomly assigned to one of two groups. The intervention group wears double-layered surgical gloves, one size smaller than measured, covered by large cotton gloves on both hands for 30 minutes before, during, and after chemotherapy. The control group wears non-compressive plastic gloves covered by large cotton gloves on both hands for the same duration. The treatment period lasts 9 weeks, coinciding with the chemotherapy schedule. During the study, data including neuropathy grades using CTCAE version 5.0, FACT/GOG-NTX scores, Patient Neurotoxicity Questionnaire results, and monofilament test outcomes are collected at weeks 0, 3, 6, and 9. Enrollment and monitoring are conducted by the Oncology Unit staff, with data recorded electronically. The primary outcome is the incidence of grade 2 or higher sensory neuropathy after 9 weeks. Statistical analyses are performed to evaluate the results, and the total participation lasts through the chemotherapy period.

Efficacy of Surgical Glove-Compression Therapy As a Prevention of Paclitaxel-Induced Peripheral Neuropathy