Actively Recruiting
Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-07-14
19
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Digital osteoarthritis is the second localization of symptomatic osteoarthritis, after the knee. Its cardinal symptoms are particularly intense pain and functional impairment in the case of the erosive form. There is currently no etiological treatment for osteoarthritis. Symptomatic treatments have a modest efficacy, which justifies the search for new treatments. The surgical options are arthrodesis or prosthesis, invasive techniques potentially sources of complications, and finally proposed infrequently given the prevalence of digital osteoarthritis. DECAD is a prospective phase II trial aimed at evaluating the efficacy of surgical joint denervation in painful digital osteoarthritis.
CONDITIONS
Official Title
Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with symptomatic digital osteoarthritis according to American College of Rheumatology criteria
- Have one painful proximal interphalangeal joint with pain score 4 or higher on a 10-point scale lasting more than 3 months
- Have not responded to usual medical treatments including level 1 analgesics, NSAIDs, or infiltrations for at least 3 months
- Signed informed consent
- Affiliated with a social security scheme
- Able to read French to complete questionnaires
You will not qualify if you...
- Digital osteoarthritis caused by other conditions such as gout, reactive arthritis, rheumatoid arthritis, psoriatic arthritis, spondyloarthropathies, or septic arthritis
- Contraindications to anesthesia or MRI
- Presence of pain syndromes in the upper limbs that could affect assessment
- Fibromyalgia diagnosis
- Use of corticosteroids, immunosuppressants, or hyaluronic acid injections in finger joints within the last month
- Started new treatments for hand osteoarthritis in the past month, including physiotherapy or new finger orthoses
- Previous denervation surgery of the proximal interphalangeal joint
- Under legal protection such as guardianship or deprived of liberty
- Under AME (state medical aid)
- Participation in another interventional research trial or within exclusion period after previous trial
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Rheumatology department Saint-Antoine Hospital
Paris, France, 75012
Actively Recruiting
Research Team
A
Adeline CAMBON-BINDER, MD PhD
CONTACT
J
Jérémie SELLAM
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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