A Proof-of-Concept Study to Assess the Efficacy of Symprove Probiotics in Managing Persistent Gastrointestinal Symptoms in Adult Coeliac Disease Patients in Histological Remission

What this Trial Is About

Coeliac Disease (CD) is a lifelong autoimmune condition where eating gluten causes damage to the small intestine. Although most people improve on a strict gluten-free diet, up to 20% continue to experience gut symptoms like bloating, pain, and diarrhoea even after their intestine has healed. This study evaluates whether a probiotic drink called Symprove, containing live good bacteria, can help relieve these ongoing symptoms by restoring a healthy balance of gut bacteria. Participants will take 70 mL of Symprove orally every day for 3 months, with an optional fourth month if they complete all assessments. Symprove is gluten-free, dairy-free, and contains specific strains of Lactobacillus and Bifidobacterium. This single-arm, open-label study involves self-administration of the probiotic at home to test its effects on gut symptoms and microbiota balance. During the study, participants’ gut symptoms will be assessed monthly, and their quality of life and gut bacteria diversity will be measured at the start and end of the 3-month period. Stool samples will be collected to analyze gut bacteria changes. The study aims to understand if Symprove can reduce symptoms and improve life for adults with coeliac disease in remission who still have digestive issues.

Efficacy of Symprove Probiotics in Coeliac Disease