Actively Recruiting
Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries
Led by Stanford University · Updated on 2024-11-27
150
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if targeted medical therapy will improve symptoms and quality of life in patients with angina and non-obstructive coronary arteries compared to placebo, after the underlying cause of the chest pain has been ascertained by coronary function testing. Participants will be treated with either medications that target the underlying cause of their chest pain or placebo for 4 weeks after a drug titration phase of 1-3 weeks. They will be asked to complete a series of questionnaires to evaluate their quality of life at the beginning and end of the study.
CONDITIONS
Official Title
Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with stable angina referred to Stanford University Hospital for coronary function testing
- No significant epicardial coronary artery disease on angiography
- Fractional flow reserve greater than 0.80
- At least one of the following: epicardial coronary spasm on acetylcholine testing, microvascular spasm on acetylcholine testing, coronary flow reserve less than 2.5, index of microcirculatory resistance 25 or higher, or myocardial bridge with resting full-cycle ratio 0.76 or less by intravascular ultrasound with dobutamine
You will not qualify if you...
- Acute coronary syndrome within one week before enrollment
- Cardiomyopathy
- Contraindications to beta-blockers or calcium channel blockers
- Baseline systolic blood pressure less than 95 mmHg
- Baseline heart rate less than 55 beats per minute
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford Hospital
Palo Alto, California, United States, 94304
Actively Recruiting
Research Team
C
Christopher Wong, MBBS, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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