Actively Recruiting
The Efficacy of Temporal Interference Stimulation in the Treatment of Obsessive-Compulsive Disorder
Led by Shanghai Mental Health Center · Updated on 2026-03-10
18
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the efficacy of Temporal Interference (TI) stimulation in treating patients with obsessive-compulsive disorder (OCD) and to explore its potential neural mechanisms using magnetic resonance imaging (MRI) and electroencephalography (EEG).
CONDITIONS
Official Title
The Efficacy of Temporal Interference Stimulation in the Treatment of Obsessive-Compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 50 years
- Diagnosed with obsessive-compulsive disorder according to DSM-5
- Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score of 20 or higher
- History of at least two adequate trials of selective serotonin reuptake inhibitors (SSRIs)
- Stable SSRI dosage for at least 8 weeks if currently treated
- At least 9 years of education
You will not qualify if you...
- Any DSM-5 diagnosis other than OCD except obsessive-compulsive personality disorder
- OCD symptoms too severe to complete assessments
- Received electroconvulsive therapy within the past 6 months
- Received other neuromodulation treatments within the past 2 months
- Severe medical illness or risk of seizures, including cardiovascular or respiratory conditions
- Neurological disorders or history of brain injury or surgery
- MRI-incompatible implants such as pacemakers, stents, or cochlear implants
- Current suicidal risk as judged by investigators
- Pregnant or planning to become pregnant during the study
- Started structured OCD psychotherapy within the last 3 months with expected changes during treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
Z
Zhen Wang, PhD,MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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