Clinical and Biochemical Assessment of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Management

What this Trial Is About

Oral leukoplakia (OL) is the most common potentially malignant disorder of the mouth's lining, with complex causes including oxidative stress. Researchers are studying the effects of two topical antioxidants, Coenzyme Q10 and curcumin, which have shown promise in reducing lesion size and stabilizing the disease to potentially prevent it from turning into oral cancer. This randomized controlled clinical trial aims to assess the clinical and biochemical effectiveness of these treatments for managing homogeneous oral leukoplakia. Participants will apply either Coenzyme Q10 gel or topical curcumin gel directly to their lesions 2 to 3 times daily for 4 weeks. This study includes two experimental groups, each receiving one of the topical antioxidant gels. The treatments are applied locally to accessible lesions, with the trial monitoring participants over this 4-week treatment period. Throughout the study, researchers will measure changes in lesion size and salivary markers at the start, after 4 weeks, and again at 12 weeks to evaluate treatment effects. Participants must be willing to follow study instructions and attend follow-up visits. Safety and effectiveness are monitored through clinical and biochemical assessments, with total participation lasting at least 12 weeks from baseline to final evaluation.

Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment