Actively Recruiting
Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment
Led by Alexandria University · Updated on 2026-01-12
34
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.
CONDITIONS
Official Title
Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically and histologically diagnosed with homogeneous oral leukoplakia not indicated for surgical excision
- Lesions accessible for topical application
- Willing to sign informed consent and comply with study instructions and return to follow up
You will not qualify if you...
- Moderate-to-severe dysplasia, carcinoma in situ, or invasive oral cancer
- Presence of any visible oral lesions except for oral leukoplakia
- Active periodontal diseases
- Significant systemic illness or immunosuppression
- Taken systemic or topical antioxidant supplements within the last four weeks
- Pregnant and lactating women
- Unwilling or unable to comply with study requirements
AI-Screening
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Trial Site Locations
Total: 1 location
1
Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt
Actively Recruiting
Research Team
T
Tasnim Saleem, BDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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